研究室オリジナルHP

医療薬学研究室

研究テーマ

疾患の発症・進展のメカニズムを解明して、創薬や合理的な薬物治療、疾患予防に貢献する

日本人の死因の多くを占めるがんや心疾患から、生活習慣病を基盤に発症する動脈硬化や認知症まで、様々な疾患を対象に、発症・進展のメカニズムを解明し、革新的新規治療法の開発に資する基礎研究を行っています。

(1) アルツハイマー型認知症における神経血管ユニットの役割
(2) 心血管病における炎症・免疫機序の解明と新規治療法の開発
(3) がん細胞の抗がん剤に対する耐性獲得機構

また、医療施設との連携による臨床検体を用いた解析や医療現場における薬物治療に関する臨床薬学研究も行っています。

スタッフ

力武 良行

力武 良行 教授

担当科目:処方解析学 処方解析演習 薬物治療学I 薬物治療学Ⅲ 薬物治療学IV アドバンスト薬物治療学 先端医療論 総合薬学講座 合同初期体験実習 医療コミュニケーション演習 IPW演習 実務実習事前教育 病態解析治療学特論(大学院) がん医療薬学特論(大学院)
学位:博士(医学)

所属学会:日本内科学会(総合内科専門医、認定内科医) 日本循環器学会(循環器専門医) 日本動脈硬化学会 日本癌学会 日本血管生物医学会(評議員) 日本分子生物学会 日本生化学会 日本薬学会
神戸大学客員教授

佐々木 直人

佐々木 直人 准教授

担当科目:処方解析学 処方解析演習 薬物治療学I アドバンスト薬物治療学 総合薬学講座 実務実習事前教育 病態解析治療学特論(大学院) がん医療薬学特論(大学院)
学位:博士(医学)

所属学会:日本内科学会(総合内科専門医、認定内科医) 日本循環器学会(循環器専門医) 日本動脈硬化学会 日本血管生物医学会 日本免疫学会 日本臨床免疫学会 日本薬学会 American Heart Association
神戸大学客員准教授

堀部 紗世

堀部 紗世 助教

担当科目:処方解析学 処方解析演習 実務実習事前教育
学位:博士(薬学)

所属学会:日本薬学会 日本癌学会 日本分子生物学会

研究成果

【著書・総説】
力武 良行. 細胞の運動と増殖の新規接触阻害機構. 生化学. 2017年, 89巻1号, p.111-114.

Yamashita T, Emoto T, Sasaki N, Hirata KI. Gut microbiota and coronary artery disease. Int Heart J. 2016;57:663-671.

Mandai K, Rikitake Y, Mori M, Takai Y. Nectins and nectin-like molecules in development and disease. Curr Top Dev Biol. 2015;112:197-231.

力武 良行. Heart View. 特集:新しい循環器病のバイオマーカー-臨床的意義を理解する-「接着分子」. 2015年11月増刊号, p.154-157.

Sasaki N, Yamashita T, Kasahara K, Takeda M, Hirata K. Regulatory T cells and tolerogenic dendritic cells as critical immune modulators in atherogenesis. Current Pharmaceutical Design. 2015;21:1107-1117.

Yamashita T, Sasaki N, Kasahara K, Hirata K. Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease. J Cardiol. 2015;66(1):1-8.

Yamashita T, Kasahara K, Emoto T, Matsumoto T, Mizoguchi T, Kitano N, Sasaki N, Hirata K. Intestinal immunity and gut microbiota as therapeutic targets for preventing atherosclerotic cardiovascular diseases. Circ J. 2015;79:1882-1890.

Mori M, Rikitake Y, Mandai K, Takai Y. Roles of nectins and nectin-like molecules in the nervous system. Adv Neurobiol. 2014;8:91-116.

【論文】
(2017)
1. Sasaki N, Yamashita T, Kasahara K, Fukunaga A, Yamaguchi T, Emoto T, Yodoi K, Matsumoto T, Nakajima K, Kita T, Takeda M, Mizoguchi T, Hayashi T, Sasaki Y, Hatakeyama M, Taguchi K, Washio K, Sakaguchi S, Malissen B, Nishigori C, Hirata K. Ultraviolet B exposure prevents atherosclerosis by regulating immuno-inflammatory responses. Arterioscler Thromb Vasc Biol. 2017;37(1):66-74.

2. Emoto T, Yamashita T, Kobayashi T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata KI. Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease. Heart Vessels. 2017;32(1):39-46.

3. Suzuki A, Fukuzawa K, Yamashita T, Yoshida A, Sasaki N, Emoto T, Takei A, Fujiwara R, Nakanishi T, Yamashita S, Matsumoto A, Konishi H, Ichibori H, Hirata K. Circulating intermediate CD14++CD16+monocytes are increased in patients with atrial fibrillation and reflect the functional remodelling of the left atrium. Europace. 2017;19(1):40-47.

4. Kasahara K, Tanoue T, Yamashita T, Yodoi K, Matsumoto T, Emoto T, Mizoguchi T, Hayashi T, Kitano N, Sasaki N, Atarashi K, Honda K, Hirata KI. Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis. J Lipid Res. 2017;58(3):519-528.

5. Terao Y, Fujita H, Horibe S, Sato J, Minami S, Kobayashi M, Matsuoka I, Sasaki N, Satomi-Kobayashi S, Hirata K, Rikitake Y. Interaction of FAM5C with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1): Implication of N-glycosylation in FAM5C secretion. Biochem Biophys Res Commun. 2017;486:811-816.

6. Mizoguchi T, Kasahara K, Yamashita T, Sasaki N, Yodoi K, Matsumoto T, Emoto T, Hayashi T, Kitano N, Yoshida N, Amin HZ, Hirata KI. Oral administration of the lactic acid bacterium Pediococcus acidilactici attenuates atherosclerosis in mice by inducing tolerogenic dendritic cells. Heart Vessels. 2017;32(6):768-776.

7. Horibe S, Kawauchi S, Yasuike S, Mizuno S, Kato I, Rikitake Y. Anti-inflammatory effect of JBP485 on dextran dulfate dodium-induced colitis in mice. J Biomed. 2017;2(2):101-108.

8. Yamana S, Tokiyama A, Fujita H, Terao Y, Horibe S, Sasaki N, Satomi-Kobayashi S, Hirata K, Rikitake Y. Necl-4 enhances the PLCγ–c-Raf–MEK–ERK pathway without affecting internalization of VEGFR2. Biochem Biophys Res Commun. 2017;490:169-175.

9. Kawashima T, Takito J, Shimada Y, Sato M, Inoue M, Miyazaki T, Miyata M, Rikitake Y, Takai Y, Nakamura M. Dynamic expression of nectins in enamel organs of mouse incisors. J Oral Biosci. 2017;59:172–178.

10. Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, Amin H. Z, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori C, Rikitake Y, Hirata K. UVB exposure inhibits angiotensin II-Induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells. J Am Heart Assoc. 2017;6(9).

(2016)
1. Horibe S, Tanahashi T, Kawauchi S, Mizuno S, Rikitake Y. Preventative effects of sodium alginate on indomethacin-induced small-intestinal injury in mice. Int. J. Med. Sci. 2016;13:653-663.

2. Miyata M, Mandai K, Maruo T, Sato J, Shiotani H, Kaito A, Itoh Y, Wang S, Fujiwara T, Mizoguchi A, Takai Y, Rikitake Y. Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain. Brain Res. 2016;1649(Pt A):90-101.

3. Kawauchi S, Nakamura T, Horibe S, Tanahashi T, Mizuno S, Hamaguchi T, Rikitake Y. Mechanism of changes in hepatic CYP3A expression in a rat model of indomethacin-induced small intestinal ulcers. Biopharm. Drug Dispos. 2016;37:522-532.

4. Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K. Overexpression of CTLA-4 prevents atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2016;36:1141-1151.

5. Emoto T, Yamashita T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata K. Analysis of gut microbiota in coronary artery disease patients: a possible link between gut microbiota and coronary artery disease. J Atheroscler Thromb. 2016;23:908-921.

6. Yamanaka K, Sasaki N, Fujita Y, Kawamoto A, Hirata KI, Okita Y. Impact of acquired and innate immunity on spinal cord ischemia and reperfusion injury. Gen Thorac Cardiovasc Surg. 2016;64:251-259.

7. Tamori A, Murakami Y, Kubo S, Itami S, Uchida-Kobayashi S, Morikawa H, Enomoto M, Takemura S, Tanahashi T, Taguchi YH, Kawada N. MicroRNA expression in hepatocellular carcinoma after the eradication of chronic hepatitis virus C infection using interferon therapy. Hepatol Res. 2016;46(3):E26-35.

(2015)
1. Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y. The cell adhesion molecule Necl-4/CADM4 serves as a novel regulator for contact inhibition of cell movement and proliferation. PLoS ONE. 2015;10(4):e0124259.

2. Terao Y, Satomi-Kobayashi S, Hirata K, Rikitake Y. Involvement of Rho-associated protein kinase (ROCK) and bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER) in high glucose-increased alkaline phosphatase expression and activity in human coronary artery smooth muscle cells. Cardiovasc Diabetol. 2015;14:104.

3. Mori S, Takaya T, Kinugasa M, Ito T, Takamine S, Fujiwara S, Nishii T, Kono A, Inoue T, Satomi-Kobayashi S, Rikitake Y, Okita Y, Hirata K. Three-dimensional quantification and visualization of aortic calcification by multidetector-row computed tomography: A simple approach using a volume-rendering method. Atherosclerosis. 2015;239(2):622-628.

4. Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R, Rikitake Y, Kiyomizu K, Tomiyama Y, Yamamoto J, Hirata K. Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors. Mol. Nutr. Food Res. 2015;59(4):729-740.

5. Inoue T, Fujiwara T, Rikitake Y, Maruo T, Mandai K, Kimura K, Kayahara T, Wang S, Itoh Y, Sai K, Mori M, Mori K, Mizoguchi A, Takai Y. Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb. J Comp Neurol. 2015; 523(12):1824-1839.

6. Fujiwara T, Inoue T, Maruo T, Rikitake Y, Nao Ieki, Mandai K, Kimura K, Kayahara T, Wang S, Itoh Y, Sai K, Mori M, Mori K, Takai Y, Mizoguchi A. Nectin-1 spots at contacts between mitral cell dendrites regulate their branching in the mouse olfactory bulb corresponding. Mol Cell Neurosci. 2015;68:143-150.

7. Yamani LN, Yano Y, Utsumi T, Juniastuti, Wandono H, Widjanarko D, Triantanoe A, Wasityastuti W, Liang Y, Okada R, Tanahashi T, Murakami Y, Azuma T, Soetjipto, Lusida MI, Hayashi Y. Ultra-deep Sequencing to Detect Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients. J Clin Microbiol. 2015;53(10):3165-3175.

8. Hayakawa M, Umeyama H, Iwadate M, Tanahashi T, Yano Y, Enomoto M, Tamori A, Kawada N, Murakami Y. Development of novel hepatitis B virus capsid inhibitor using in silico screening. Biochem Biophys Res Commun. 2015;463(4):1165-75.

9. Horibe S, Matsuda A, Tanahashi T, Inoue J, Kawauchi S, Mizuno S, Ueno M, Takahashi K, Maeda Y, Maegouchi T, Murakami Y, Yumoto R, Nagai J, Takano M. Cisplatin resistance in human lung cancer cells is linked with dysregulation of cell cycle associated proteins. Life Sci. 2015;124:31-40.

10. Murakami Y, Hayakawa M, Yano Y, Tanahashi T, Enomoto M, Tamori A, Kawada N, Iwadate M, Umeyama H. Discovering novel direct acting antiviral agents for HBV using in silico screening. Biochem Biophys Res Commun. 2015;456(1):20-28.

11. Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T, Hirata K. Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice. Hypertension. 2015;65:889-895.

(2014)
1. Fukuda T, Kominami K, Wang S, Togashi H, Hirata KI, Rikitake Y, Takai Y. Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014;141(2):399-409.

2. Sato J, Kinugasa M, Satomi-Kobayashi S, Hatakeyama K, Knox AJ, Asada Y, Wierman ME, Hirata K, Rikitake Y. Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: Implication in vascular inflammation. PLoS One. 2014;9(9):e107236.

3. Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, Takai Y. s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin. Genes Cells. 2014;19(12):853-863.

4. Kawauchi S, Nakamura T, Yasui H, Nishikawa C, Miki I, Inoue J, Horibe S, Hamaguchi T, Tanahashi T, Mizuno S. Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. Int J Med Sci. 2014;11(12):1208-1217.

5. Murakami Y, Tanahashi T, Okada R, Toyoda H, Kumada T, Enomoto M, Tamori A, Kawada N, Taguchi YH, Azuma T. Comparison of Hepatocellular Carcinoma miRNA Expression Profiling as Evaluated by Next Generation Sequencing and Microarray. PLoS One. 2014;9(9):e106314.

6. Iwamoto A, Tanahashi T, Okada R, Yoshida Y, Kikuchi K, Keida Y, Murakami Y, Yang L, Yamamoto K, Nishiumi S, Yoshida M, Azuma T. Whole-genome sequencing of clarithromycin resistant Helicobacter pylori characterizes unidentified variants of multidrug resistant efflux pump genes. Gut Pathog. 2014;6:27.

7. Kawauchi S, Nakamura T, Miki I, Inoue J, Hamaguchi T, Tanahashi T, Mizuno S. Downregulation of CYP3A and P-Glycoprotein in the Secondary Inflammatory Response of Mice With Dextran Sulfate Sodium-Induced Colitis and Its Contribution to Cyclosporine A Blood Concentrations. J Pharmacol Sci. 2014;124(2):180-191.

8. Kano S, Nishida K, Kurebe H, Nishiyama C, Kita K, Akaike Y, Kajita K, Kurokawa K, Masuda K, Kuwano Y, Tanahashi T, Rokutan K. Oxidative stress-inducible truncated serine/arginine-rich splicing factor 3 regulates interleukin-8 production in human colon cancer cells. Am J Physiol Cell Physiol. 2014;306(3):C250-262.

9. Kurokawa K, Akaike Y, Masuda K, Kuwano Y, Nishida K, Yamagishi N, Kajita K, Tanahashi T, Rokutan K. Down-regulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. Oncogene. 2014;33(11):1407-1417.

10. Bao W, Morimoto K, Hasegawa T, Sasaki N, Yamashita T, Hirata K, Okita Y, Okada K. Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats. J Vasc Surg. 2014;59:1098-1108.

11. Kita T, Yamashita T, Sasaki N, Kasahara K, Sasaki Y, Yodoi K, Takeda M, Nakajima K, Hirata K. Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T cell response in mice. Cardiovasc Res. 2014;102:107-117.

12. Kasahara K, Sasaki N, Yamashita T, Kita T, Yodoi K, Sasaki Y, Takeda M, Hirata K. CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response. J Am Heart Assoc. 2014;3:e000719.

13. Nagano T, Edamatsu H, Kobayashi K, Takenaka N, Yamamoto M, Sasaki N, Nishimura Y, Kataoka T. Phospholipase Cε, an effector of Ras and Rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma. PLoS One. 2014;9(9):e108373.

14. Emoto T, Sasaki N, Yamashita T, Kasahara K, Yodoi K, Sasaki Y, Matsumoto T, Mizoguchi T, Hirata K. The regulatory/effector T cell ratio is reduced in coronary artery disease. Circ J. 2014;78:2935-2941.

15. Amin HZ, Mori S, Sasaki N, Hirata K. Diagnostic approach to cardiac amyloidosis. Kobe J Med Sci. 2014;60(1):E5-E11.