英文原書

2019年

Adhikara IM, Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata KI, Emoto N. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. Biochem Biophys Res Commun. (2019) 509:89-95.

2018年

Sano H, Tanaka H, Motoji Y, Mukai J, Suto M, Takada H, Soga F, Hatani Y, Matsuzoe H, Hatazawa K, Shimoura H, Ooka J, Nakayama K, Matsumoto K, Yamada H, Emoto N, Hirata KI. Echocardiography during preload stress for evaluation of right ventricular contractile reserve and exercise capacity in pulmonary hypertension. Echocardiography. (2018) 35:1997-2004.

Yorifuji K, Uemura Y, Horibata S, Tsuji G, Suzuki Y, Miyagawa K, Nakayama K, Hirata KI, Kumagai S, Emoto N. Corrigendum to "CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension. Pharmacol. Res. (2018) S1043-6618(18)31413-0.

Nugroho DB, Ikeda K, Kajimoto K, Hirata KI, Emoto N. Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis. Biochem Biophys Res Commun. (2018) 504:427-433.

Nakayama K, Emoto N, Tamada N, Okano M, Shinkura Y, Yanaka K, Onishi H, Hiraishi M, Yamada S, Tanaka H, Shinke T, Hirata KI. The optimization of iloprost inhalation under moderate flow of oxygen therapy in severe pulmonary arterial hypertension. Pulm Circ. (2018) 8:2045894018781537.

Nugroho DB, Ikeda K, Barinda AJ, Wardhana DA, Yagi K, Miyata K, Oike Y, Hirata KI, Emoto N. Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature. Biochem Biophys Res Commun. (2018) 503:378-384.

Yorifuji K, Uemura Y, Horibata S, Tsuji G, Suzuki Y, Miyagawa K, Nakayama K, Hirata KI, Kumagai S, Emoto N. CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension. Pharmacol Res. (2018) 135:259-264.

Okano M, Nakayama K, Tamada N, Shinkura Y, Yanaka KI, Onishi H, Tanaka H, Shinke T, Tanaka H, Okita Y, Emoto N, Hirata KI. Reversible Parkinsonism and Multiple Cerebral Infarctions after Pulmonary Endarterectomy in a Patient with Antiphospholipid Syndrome. Intern Med. (2018) 57:2019-2023.

Qurania KR, Ikeda K, Wardhana DA, Barinda AJ, Nugroho DB, Kuribayashi Y, Rahardini EP, Rinastiti P, Ryanto GRT, Yagi K, Hirata KI, Emoto N. Systemic inhibition of Janus kinase induces browning of white adipose tissue and ameliorates obesity-related metabolic disorders. Biochem Biophys Res Commun. (2018) 502:123-128.

Hartopo AB, Arfian N, Nakayama K, Suzuki Y, Yagi K, Emoto N. Endothelial-derived endothelin-1 promotes pulmonary vascular remodeling in bleomycin-induced pulmonary fibrosis. Physiol Res. (2018) 67(Supplementum 1):S185-S197.

Arfian N, Kusuma MH, Anggorowati N, Nugroho DB, Jeffilano A, Suzuki Y, Ikeda K, Emoto N. Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice. Physiol Res. (2018) 67(Supplementum 1):S137-S147.

Yanaka K, Nakayama K, Shinke T, Shinkura Y, Taniguchi Y, Kinutani H, Tamada N, Onishi H, Tsuboi Y, Satomi-Kobayashi S, Otake H, Tanaka H, Okita Y, Emoto N, Hirata KI. Sequential Hybrid Therapy With Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. J Am Heart Assoc. (2018) 7:e008838.

Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Tsuboi Y, Izawa KP, Satomi-Kobayashi S, Otake H, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata KI. Early Introduction of Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension. JACC Cardiovasc Interv. (2018) 11:1114-1116.

Shinkura Y, Nakayama K, Yanaka K, Kinutani H, Tamada N, Tsuboi Y, Satomi-Kobayashi S, Otake H, Shinke T, Emoto N, Hirata KI. Extensive revascularisation by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond haemodynamic normalisation. EuroIntervention. (2018) 13:2060-2068.

Wardhana DA, Ikeda K, Barinda AJ, Nugroho DB, Qurania KR, Yagi K, Miyata K, Oike Y, Hirata KI, Emoto N. Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis. Proc Natl Acad Sci USA. (2018) 115:1529-1534.

2017年

Tamada N, Nakayama K, Shinkura Y, Yanaka K, Katayama N, Okada T, Yamaguchi M, Matsumoto K, Tanaka H, Shinke T, Emoto N, Hirata KI. Successful Pulmonary Artery Embolization for the Management of Hemoptysis in a Patient with Eisenmenger Syndrome Caused by Patent Ductus Arteriosus. Intern Med. (2017) 56:3299-3304.

Takeuchi K, Nakayama K, Okano M, Tamada N, Suehiro H, Shinkura Y, Yanaka K, Onishi H, Tanaka H, Shinke T, Emoto N, Hirata KI. Upfront triple combination therapy-induced pulmonary edema in a case of pulmonary arterial hypertension associated with Sjogren's syndrome. Respir Med Case Rep. (2017) 7;23:55-59.

Barinda AJ, Ikeda K, Hirata KI, Emoto N. Macrophages Highly Express Carbonic Anhydrase 2 and Play a Significant Role in Demineralization of the Ectopic Calcification. Kobe J Med Sci. (2017) 63: E45-E50.

Ogawa A, Satoh T, Fukuda T, Sugimura K, Fukumoto Y, Emoto N, Yamada N, Yao A, Ando M, Ogino H, Tanabe N, Tsujino I, Hanaoka M, Minatoya K, Ito H, Matsubara H. Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Results of a Multicenter Registry. Circ Cardiovasc Qual Outcomes. (2017) 10:e004029

Tsuboi Y, Tanaka H, Nishio R, Sawa T, Terashita D, Nakayama K, Satomi-Kobayashi S, Sakai Y, Emoto N, Hirata KI. Associations of Exercise Tolerance With Hemodynamic Parameters for Pulmonary Arterial Hypertension and for Chronic Thromboembolic Pulmonary Hypertension. J Cardiopulm Rehabil Prev. (2017) 37: 341-346.

Hayashi D, Yagi K, Song C, Ueda S, Yamanoue M, Topham M, Suzaki T, Saito N, Emoto N, Shirai Y. Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice. Sci Rep. (2017) 7: 2597.

Sano H, Tanaka H, Motoji Y, Fukuda Y, Mochizuki Y, Hatani Y, Matsuzoe H, Hatazawa K, Shimoura H, Ooka J, Ryo-Koriyama K, Nakayama K, Matsumoto K, Emoto N, Hirata KI. Right ventricular relative wall thickness as a predictor of outcomes and of right ventricular reverse remodeling for patients with pulmonary hypertension. Int J Cardiovasc Imaging. (2017) 33:313-321.

2016年

Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A. Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res Ther. (2016) 18: 113

Fukuda Y, Tanaka H, Ryo-Koriyama K, Motoji Y, Sano H, Shimoura H, Ooka J, Toki H, Sawa T, Mochizuki Y, Matsumoto K, Emoto N, Hirata KI. Comprehensive Functional Assessment of Right-Sided Heart Using Speckle Tracking Strain for Patients with Pulmonary Hypertension. Echocardiography. (2016)33: 1001-1008

Motoji Y, Tanaka H, Fukuda Y, Sano H, Ryo K, Sawa T, Miyoshi T, Imanishi J, Mochizuki Y, Tatsumi K, Matsumoto K, Emoto N, Hirata KI. Association of Apical Longitudinal Rotation with Right Ventricular Performance in Patients with Pulmonary Hypertension: Insights into Overestimation of Tricuspid Annular Plane Systolic Excursion. Echocardiography.(2016) 33: 207-215

2015年

Kinutani H, Shinke T, Nakayama K, Taniguchi Y, Otake H, Takaya T, Osue T, Konishi A, Emoto N, Hirata KI. High perfusion pressure as a predictor of reperfusion pulmonary injury after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. IJC Heart & Vasc. (2015)11:1-6.

Muliawan HS, Nakayama K, Yagi K, Ikeda K, Yagita K, Hirata K, Emoto N. Stable Somatic Gene Expression in Mouse Lungs Following Electroporation-mediated Tol2 Transposon Delivery. (2015) Kobe J Med Sci. 61(2):E47-53.

Satwiko MG, Ikeda K, Nakayama K, Yagi K, Hocher B, Hirata K, Emoto N. Targeted activation of endothelin-1 exacerbates hypoxia-induced pulmonary hypertension. (2015) Biochem Biophys Res Commun. 465(3):356-62.

Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Takamura K, Hanaoka M, Nishimura M, Tatsumi K; JRS Lung Disease PH Study Group. Multi-institutional retrospective cohort study of patients with severe pulmonary hypertension associated with respiratory diseases. (2015) Respirology. 20(5):805-12.

Sano H, Tanaka H, Motoji Y, Fukuda Y, Sawa T, Mochizuki Y, Ryo K, Matsumoto K, Emoto N, Hirata K. Right ventricular function and right-heart echocardiographic response to therapy predict long-term outcome in patients with pulmonary hypertension. (2015) Can J Cardiol. 31(4):529-36.

Motoji Y, Tanaka H, Fukuda Y, Sano H, Ryo K, Imanishi J, Miyoshi T, Sawa T, Mochizuki Y, Matsumoto K, Emoto N, Hirata K. Interdependence of right ventricular systolic function and left ventricular filling and its association with outcome for patients with pulmonary hypertension. (2015) Int J Cardiovasc Imaging. 331(4):691-8.

Matsuo K, Akakabe Y, Kitamura Y, Shimoda Y, Ono K, Ueyama T, Matoba S, Yamada H, Hatakeyama K, Asada Y, Emoto N, Ikeda K. Loss of apoptosis regulator through modulating IAP expression (ARIA) protects blood vessels from atherosclerosis. (2015) J Biol Chem. 290(6):3784-92.

Nakamoto H, Nakayama K, Emoto N, Kajiya F. The short-term effects of C-peptide on the early diabetes-related ultrastructural changes to the podocyte slit diaphragm of glomeruli in rats. (2015) Microcirculation. 22(2):122-32.

Teguh Ryanto GR, Nakayama K, Takaya T, Fujimoto D, Kinutani H, Shinkura Y, Mori S, Okada T, Nishii T, Kono A, Shinke T, Emoto N, Hirata K. Use of Coils and a Pulmonary Vasodilator to Reduce Pulmonary Hypertension in a Patient with Interstitial Pneumonia and Scleroderma. (2015) Intern Med. 54(21):2721-6.

Shimoda Y, Matsuo K, Kitamura Y, Ono K, Ueyama T, Matoba S, Yamada H, Wu T, Chen J, Emoto N, Ikeda K. Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle. (2015) PLoS One. 10(9):e0138624.

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2014年

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. (2014) Life Sci. 118(2):70-6.

Emoto N, Masaki T, Goto K, Vanhoutte PM, Yanagisawa M. Endothelin XIII. (2014) Life Sci. 118(2):47-50.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. (2014) Life Sci. 118(2):77-86.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award 2013. (2014) Life Sci. 118(2):87-90.

Van Hung T, Emoto N, Vignon-Zellweger N, Nakayama K, Yagi K, Suzuki Y, Hirata KI. Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: Potential roles of interleukin-6 and endothelin. (2014) Life Sci. 24;118(2):313-328.

Fukuda Y, Tanaka H, Motoji Y, Ryo K, Sawa T, Imanishi J, Miyoshi T, Mochizuki Y, Tatsumi K, Matsumoto K, Shinke T, Emoto N, Hirata KI. Utility of combining assessment of right ventricular function and right atrial remodeling as a prognostic factor for patients with pulmonary hypertension. (2014) Int J Cardiovasc Imaging. 30(7):1269-1277.

Miyagawa K, Emoto N. Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension. (2014) Ther Adv Cardiovasc Dis. 8(5):202-216.

Taniguchi Y, Miyagawa K, Nakayama K, Kinutani H, Shinke T, Okada K, Okita Y, Hirata KI, Emoto N. Balloon pulmonary angioplasty: an additional treatment option to improve the prognosis of patients with chronic thromboembolic pulmonary hypertension. (2014) EuroIntervention. 10(4):518-25.

Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Miyaji K, Takamura K, Hayashi S, Hanaoka M, Tatsumi K; Japanese Respiratory Society Lung Disease Pulmonary Hypertension Study Group. Current trends in the management of pulmonary hypertension associated with respiratory disease in institutions approved by the Japanese Respiratory Society. (2014) Respir Investig. 52(3):167-172.

Taniguchi Y, Emoto N, Miyagawa K, Nakayama K, Kinutani H, Tanaka H, Shinke T, Okada K, Okita Y, Hirata KI. Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports: strategy for ASD with severe PAH. (2014) Heart Vessels. 29(2):282-285.

Nugrahaningsih DA, Emoto N, Vignon-Zellweger N, Purnomo E, Yagi K, Nakayama K, Doi M, Okamura H, Hirata K. Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice. (2014) Hypertens Res. 37(3):202-209.

Miyagawa K, Iwasa N, Nakayama K, Hirata K, Emoto N. Pregnancy and delivery in women with renovascular hypertension due to multiple intrarenal microaneurysms: a report of two cases. (2014) Intern Med. 53(20):2325-8.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. (2014) PLoS One. 22;9(5):e97972.

Heiden S, Vignon-Zellweger N, Masuda S, Yagi K, Nakayama K, Yanagisawa M, Emoto N. Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice. (2014) PLoS One. 11;9(2):e88730.

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