Hirokazu Nakayama
Profile
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1985 D. Sc. | Doctor of Science in Physical and Inorganic Chemistry, Osaka University |
| 1986 | Research Associate, Dept. of Chemistry, College of General Education, Osaka Univ. | |
| 1989 | Visiting Scientist, Dept. of Chemistry, Univ. of Liverpool, UK | |
| 1993 | Post-doctral Fellow, NRC Summit, CA | |
| 1994 | Research Associate, Dept. of Physical Chemistry, Osaka University | |
| 1996 | Research Associate, Dept. of Chemistry, Graduate School of Science, Osaka Univ. | |
| 1997 | Assistant Professor, Kobepharmaceutical Univ. | |
| 2005-present | Professor, Kobepharmaceutical Univ. |
Reserch Projects
The carrier of various drugs is examined and put to practical use to use a drug effectively. I examine the various types of organic and inorganic material aiming at development of carrier of the new type in the functional molecular chemistry laboratory. I assume it drug carrier (DDS carrier) through the examination of these materials and perform food, medical supplies, cosmetics and the development to the environmental material.
The phosphate attracts attention as the functional material, which the various fields can use and plays an important role among the living bodies as DNA and a component of ATP. We synthesized functional compound utilizing characteristic of phosphate. The interlayer space of inorganic layered phosphate can be designed freely, and development of the tailor maid environmental material, which can remove various environmental pollution materials.
The cyclodextrin of the ringed oligosaccharide can include and stabilize various organic compounds, and has been used in the fields such as food, cosmetics. Aiming for adding new function to this cyclodextrin, I examine esterification or the polymerism. The stabilization of the drug, which had difficulty with stabilization conventionally or lytic improvement are enabled hereby.
The
hydrotalcite where it is done antacid of having much to do as so-called
digestive medicine is one of layered clays. I can immobilize various molecules and ions
between the layers. The stabilization of
various drugs is possible and, using this characteristic, examines possibility
as DDS carrier. In addition, the clay is used as a binder of cosmetics widely
and examines the possibility as the new cosmetics material.
Position of Post Doctoral Fellowship is open. Application of PD fellow
is welcome. Please contact Hirokazu Nakayama (hiro@kobepharma-u.ac.jp).
Publication Lists
2009
Complete
Protection of Sodium Valproate from Humidity by Using a Hydrotalcite Composite
H. Nakayama, H, Akasaka, and M. Tsuhako,J. Pharm. Sci., 98(1) 46-49 (2009).
Intercalation
of Melamine into Layered Zirconium Phosphates and Their Adsorption Properties
of Formaldehyde in Gas and Solution Phase
A. Hayashi, H. Nakayama, and M. Tsuhako,Solid State
Sciences,11(5), 1007-1015 (2009).
Phosphorylation
of Polyamidoamine Dendrimers with cyclo-Triphosphate
in Aqueous Solution
H. Maeda, M. Matsushita, M. Tsuhako, H. Nariai, and H.
Nakayama,Phosphorus Res.
Bull.,23, 52 ? 56 (2009).
Intercalation of Organic Molecules into Layered
Phosphates ?Correlation between Structure and Function-
H. Nakayama Phosphorus Res. Bull., 23, 1 - 9 (2009).
2008
Preparation of Silylated
a-Zirconium Phosphate and
its Thermal Behavior
T. Takei, N. Kumada, N. Kinomura, H. Nakayama, and M.
Tsuhako Mater. Res.
Bull., 43(1),
111-119 (2008).
Controlled Release of Drug from
Cyclodexrin Intercalated Layered Double Hydroxide
H.
Nakayama, K. Kuwano, and M. Tsuhako, J.
Phys. Chem. Solids,69(5-6),
1552-1555 (2008).
Intercalation of Biogenic Amines into
Layered Zirconium Phosphates
A. Hayashi,
Y. Yoshikawa, N. Ryu,H. Nakayama, M. Tsuhako and T. Eguchi
Phosphorus Res. Bull., 22, 48-53 (2008).
Posphorylation of Nucleosides and Nucleotides with Inorganic Monoimido-cyclo-TriphosphateH.Maeda, T. Chiba, M. Tsuhako, and H. Nakayama, Chem. Pharm. Bull., 56(12) 1698-1703(2008). Selected as cover paper in Chem. Pharm. Bull., volume 56, issue 12
2007
Intercalation Behavior
of L-Ascorbic Acid into Layered Double
Hydroxides
S. Aisawa, N. Higashiyama, S. Takahashi, H. Hirahara,
D. Ikematsu, H. Kondo, H. Nakayama, and E. Narita Applied Clay
Sci., 35(3-4),
146-154 (2007).
Phosphorylation
of D-Glucose
and Gluco-oligosaccharides with Diimido-cyclo-triphosphate
H. Maeda, H. Nakayama, H. Nariai, and M. Tsuhako Phosphorus Res.
Bull.,21, 38-43 (2007).
Influence of
Urea Addition on Preparation and Acidic Properties of Amorphous Lanthanum
Pyrophosphate
H. Onoda, Y. Ishima, H. Nakayama, and I. Tanaka Phosphorus Res.
Bull.,21, 53-59 (2007).
Selective
Adsorption of Mercury Ions by Mercaptocarboxylic Acid Intercalated Mg-Al
Layered Double Hydroxide
H. Nakayama, S. Hirami, and M. Tsuhako
J. Colloid
Interface Sci.,315(1), 177-183(2007).
Phosphorylation
of Saccharides by Inorganic cyclo-Triphosphate
H. Maeda, H. Nakayama, and M. Tsuhako Phosphorus Res.
Bull., 21,
103-110 (2007).
2006
Intercalation
of Glucosamine and Chitosan into Layered Zirconium Phosphates
A.Hayashi, Y.
Nakabayashi, J. Yasutomi, H. Nakayama, and M. Tsuhako Bull. Chem. Soc.
Jpn., 79(2),
262-269 (2006).
Synthesis of p-Sulfonated Calix[4]arene-intercalated Layered
Double Hydroxides and Their Adsorption Properties for Organic Molecules
S. Sasaki, S. Aisawa, H. Hirahara, A. Sasaki, H.
Nakayama and E. Narita J. Eur. Cer.
Soc.,26(4,5) 655-659 (2006).
Synthesis and Adsorption
Properties of p-Sulfonated Calix[4
and 6]arene-intercalated Layered Double Hydroxides
S. Sasaki, S. Aisawa, H. Hirahara, A. Sasaki, H. Nakayama, and E.
Narita J. Solid State Chem., 179(4), 1129-1135
(2006).
Hydrolyses of Calcium
Phosphates-allografts Composite in Physiological Solutions
T. Nomoto, K. Haraguchi, S. Yamaguchi, N. Sugano, H. Nakayama, T. Sekino, and K. NiiharaJ. Mater. Sci. Mater. Med., 17(4), 379-385 (2006).
Intercalation of Amino Acids and Oligopeptides into Zn-Al Layered
Double Hydroxide by Coprecipitation Reaction
S. Aisawa, S. Sasaki, S.
Takahashi, H. Hirahara, H. Nakayama, and E. Narita J. Phys. Chem. Solids, 67(5-6), 920-925 (2006).
Phosphorylation
of D-Glucose Derivatives with
Inorganic Monoimido-cyclo-triphosphate
H. Inoue, T. Yamada, H. Nakayama, and M. Tsuhako Chem. Pharm.
Bull., 54(10),
1397-1402 (2006).
2005
Adsorption of Gaseous Formaldehyde and Carboxylic
Acids by Ammonium-exchanged a-Zirconium
Phosphate
A.Hayashi, Y.
Fujimoto, Y. Ogawa, H. Nakayama, and M. TsuhakoJ. Colloid Inerface Sci.,281(1), 57-63 (2005).
Regioselective Phosphorylation of Branched
Cyclodextrins with Inorganic Mono-µ-imidotriphosphate
H. Inoue, T.
Kawashita, H. Nakayama, and M. Tsuhako Carbohydr. Res, 340(11), 1766-1772 (2005).
Adsorption of Gaseous Thiols and Sulfides by Ag+
ion-exchanged Aluminium Dihydrogen Triphosphate
A. Hayashi, H.
Saimen, N. Watanabe, H. Kimura, A. Kobayashi, H. Nakayama, and M. TsuhakoLangmuir,21(16), 7238-7242 (2005).
Syntheses of Organic Phosphorus Compounds with -NH-P-NH- and -NH-P-O- Bonds
by Inorganic Monoimido-cyclo-triphosphate
H. Inoue, H.
Nakayama, H. Nariai, and M. Tsuhako Phosphorus Res. Bull.,19, 319-324 (2005).
Preparation of
Nano-porous Aluminum Phsophate Using Urea and hexametylenetetramine
H. Onoda, S.
Ukita, A. Hayashi, A. Takenaka, and K. Kojima Phosphorus Res. Bull., 19, 209-214 (2005).
List of 1996-2004
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