Aiming for new types of drug delivery
carrier, various types of materials, including inorganic and organic compounds,
have been considered in our laboratory.
Selected as TOP 10 Articles Published In The Same Domain, All Time (BioMedLib)
The paper of Professor Hirokazu Nakayama, “Selective Adsorption of Mercury Ion by Mercaptocarboxylic Acid Intercalated Mg-Al Layered Double Hydroxide,” H. Nakayama, S. Hirami, and M. Tsuhako, J Colloid Interface Sci., 315(1), 177-83 (2007) was selected as one of top 10 papers of the same domain from BioMedLib.
Selected as Cover Paper of Chem. Pharm. Bull.
The paper of Research Associate Hideko Maeda, “Phosphorylation of Nucleoside and Nucleotides with Inorganic Monoimido-cyclo-Triphosphate,” H. Inoue, T. Chiba, M. Tsuhako, and H. Nakayama, Chem. Pharm. Bull., 56(12), 1698-1703(2008) was selected as top cover paper of volume 12 of Chem. Pharm. Bull. in 2008. This paper showed the conventional synthetic method of nucleotide analog using inorganic cyclic- phosphate, monoimido-cyclo-triphosphate.
Complete Protection of Hygroscopic Property of Sodium Valproate
Sodium valproate is known as anti-epilepsy drug. However, sodium valproate is very hygroscopic and shows deliquescence within few hours. By combining hydrotalcite, known as antacid drug, with sodium valproate, complete protection of humid was attained successfully.
Selected as Most Cited Paper 2004 in Int. J. Pharm.
The paper ”Intercalation of Amino Acids and Peptides into Layered Double Hydroxide by Reconstruction Method,” H. Nakayama, N. Wada, and M. Tsuhako, Int. J. Pharm., 269(2), 469-478 (2004) obtained Award of Most Cited Paper 2004. This paper showed the hybridization of amino acids with hydrotalcite aiming for the immobilization of protein and peptide.
Position of Post Doctoral Fellowship is
open. Application of PD fellow is
welcome. Please contact Hirokazu Nakayama (hiro@kobepharma-u.ac.jp).
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