@@@Hirokazu Nakayama

Profile

1985 D. Sc. Doctor of Science in Physical and Inorganic Chemistry, Osaka University
1986 Research Associate, Dept. of Chemistry, College of General Education, Osaka Univ.
1989 Visiting Scientist, Dept. of Chemistry, Univ. of Liverpool, UK
1993 Post-doctral Fellow, NRC Summit, CA
1994 Research Associate, Dept. of Physical Chemistry, Osaka University
1996 Research Associate, Dept. of Chemistry, Graduate School of Science, Osaka Univ.
1997 Assistant Professor, Kobepharmaceutical Univ.
2005-present Professor, Kobepharmaceutical Univ.

Reserch Projects

The carrier of various drugs is examined and put to practical use to use a drug effectively.  I examine the various types of organic and inorganic material aiming at development of carrier of the new type in the functional molecular chemistry laboratory. I assume it drug carrier (DDS carrier) through the examination of these materials and perform food, medical supplies, cosmetics and the development to the environmental material.

  The phosphate attracts attention as the functional material, which the various fields can use and plays an important role among the living bodies as DNA and a component of ATP.  We synthesized functional compound utilizing characteristic of phosphate.  The interlayer space of inorganic layered phosphate can be designed freely, and development of the tailor maid environmental material, which can remove various environmental pollution materials.

  The cyclodextrin of the ringed oligosaccharide can include and stabilize various organic compounds, and has been used in the fields such as food, cosmetics. Aiming for adding new function to this cyclodextrin, I examine esterification or the polymerism. The stabilization of the drug, which had difficulty with stabilization conventionally or lytic improvement are enabled hereby.

  The hydrotalcite where it is done antacid of having much to do as so-called digestive medicine is one of layered clays.  I can immobilize various molecules and ions between the layers.  The stabilization of various drugs is possible and, using this characteristic, examines possibility as DDS carrier. In addition, the clay is used as a binder of cosmetics widely and examines the possibility as the new cosmetics material.


Position of Post Doctoral Fellowship is open.  Application of PD fellow is welcome.  Please contact Hirokazu Nakayama (hiro@kobepharma-u.ac.jp).

Publication Lists

2009

Complete Protection of Sodium Valproate from Humidity by Using a Hydrotalcite Composite
H. Nakayama, H, Akasaka, and M. Tsuhako,
J. Pharm. Sci., 98(1) 46-49 (2009).

Intercalation of Melamine into Layered Zirconium Phosphates and Their Adsorption Properties of Formaldehyde in Gas and Solution Phase
A. Hayashi, H. Nakayama, and M. Tsuhako,Solid State Sciences,11(5), 1007-1015 (2009).

Phosphorylation of Polyamidoamine Dendrimers with cyclo-Triphosphate in Aqueous Solution
H. Maeda, M. Matsushita, M. Tsuhako, H. Nariai, and H. Nakayama,Phosphorus Res. Bull.,23, 52 ? 56 (2009).

Intercalation of Organic Molecules into Layered Phosphates ?Correlation between Structure and Function-
H. Nakayama Phosphorus Res. Bull., 23, 1 - 9 (2009).

2008

Preparation of Silylated a-Zirconium Phosphate and its Thermal Behavior
T. Takei, N. Kumada, N. Kinomura, H. Nakayama, and M. Tsuhako Mater. Res. Bull., 43(1), 111-119 (2008).

Controlled Release of Drug from Cyclodexrin Intercalated Layered Double Hydroxide
H. Nakayama, K. Kuwano, and M. Tsuhako, J. Phys. Chem. Solids,69(5-6), 1552-1555 (2008).

Intercalation of Biogenic Amines into Layered Zirconium Phosphates
A. Hayashi, Y. Yoshikawa, N. Ryu,H. Nakayama, M. Tsuhako and T. Eguchi
Phosphorus Res. Bull., 22, 48-53 (2008).

Posphorylation of Nucleosides and Nucleotides with Inorganic Monoimido-cyclo-TriphosphateH.Maeda, T. Chiba, M. Tsuhako, and H. Nakayama, Chem. Pharm. Bull., 56(12) 1698-1703(2008). Selected as cover paper in Chem. Pharm. Bull., volume 56, issue 12


2007

Intercalation Behavior of L-Ascorbic Acid into Layered Double Hydroxides
S. Aisawa, N. Higashiyama, S. Takahashi, H. Hirahara, D. Ikematsu, H. Kondo, H. Nakayama, and E. Narita Applied Clay Sci., 35(3-4), 146-154 (2007).

Phosphorylation of D-Glucose and Gluco-oligosaccharides with Diimido-cyclo-triphosphate
H. Maeda, H. Nakayama, H. Nariai, and M. Tsuhako Phosphorus Res. Bull.,21, 38-43 (2007).

Influence of Urea Addition on Preparation and Acidic Properties of Amorphous Lanthanum Pyrophosphate
H. Onoda, Y. Ishima, H. Nakayama, and I. Tanaka Phosphorus Res. Bull.,21, 53-59 (2007).

Selective Adsorption of Mercury Ions by Mercaptocarboxylic Acid Intercalated Mg-Al Layered Double Hydroxide
H. Nakayama, S. Hirami, and M. Tsuhako
J. Colloid Interface Sci.,315(1), 177-183(2007).

Phosphorylation of Saccharides by Inorganic cyclo-Triphosphate
H. Maeda, H. Nakayama, and M. Tsuhako Phosphorus Res. Bull., 21, 103-110 (2007).


2006

Intercalation of Glucosamine and Chitosan into Layered Zirconium Phosphates
A.Hayashi, Y. Nakabayashi, J. Yasutomi, H. Nakayama, and M. Tsuhako Bull. Chem. Soc. Jpn., 79(2), 262-269 (2006).

Synthesis of p-Sulfonated Calix[4]arene-intercalated Layered Double Hydroxides and Their Adsorption Properties for Organic Molecules
S. Sasaki, S. Aisawa, H. Hirahara, A. Sasaki, H. Nakayama and E. Narita J. Eur. Cer. Soc.,26(4,5) 655-659 (2006).

Synthesis and Adsorption Properties of p-Sulfonated Calix[4 and 6]arene-intercalated Layered Double Hydroxides
S. Sasaki, S. Aisawa, H. Hirahara, A. Sasaki, H. Nakayama, and E. Narita J. Solid State Chem., 179(4), 1129-1135 (2006).

Hydrolyses of Calcium Phosphates-allografts Composite in Physiological Solutions
T. Nomoto, K. Haraguchi, S. Yamaguchi, N. Sugano, H. Nakayama, T. Sekino, and K. NiiharaJ. Mater. Sci. Mater. Med., 17(4), 379-385 (2006).

Intercalation of Amino Acids and Oligopeptides into Zn-Al Layered Double Hydroxide by Coprecipitation Reaction
S. Aisawa, S. Sasaki, S. Takahashi, H. Hirahara, H. Nakayama, and E. Narita J. Phys. Chem. Solids, 67(5-6), 920-925 (2006).

Phosphorylation of D-Glucose Derivatives with Inorganic Monoimido-cyclo-triphosphate
H. Inoue, T. Yamada, H. Nakayama, and M. Tsuhako Chem. Pharm. Bull., 54(10), 1397-1402 (2006).


2005

Adsorption of Gaseous Formaldehyde and Carboxylic Acids by Ammonium-exchanged a-Zirconium Phosphate
A.Hayashi, Y. Fujimoto, Y. Ogawa, H. Nakayama, and M. TsuhakoJ. Colloid Inerface Sci.,281(1), 57-63 (2005).

Regioselective Phosphorylation of Branched Cyclodextrins with Inorganic Mono-µ-imidotriphosphate
H. Inoue, T. Kawashita, H. Nakayama, and M. Tsuhako Carbohydr. Res, 340(11), 1766-1772 (2005).

Adsorption of Gaseous Thiols and Sulfides by Ag+ ion-exchanged Aluminium Dihydrogen Triphosphate
A. Hayashi, H. Saimen, N. Watanabe, H. Kimura, A. Kobayashi, H. Nakayama, and M. TsuhakoLangmuir,21(16), 7238-7242 (2005).

Syntheses of Organic Phosphorus Compounds with -NH-P-NH- and -NH-P-O- Bonds by Inorganic Monoimido-cyclo-triphosphate
H. Inoue, H. Nakayama, H. Nariai, and M. Tsuhako Phosphorus Res. Bull.,19, 319-324 (2005).

Preparation of Nano-porous Aluminum Phsophate Using Urea and hexametylenetetramine
H. Onoda, S. Ukita, A. Hayashi, A. Takenaka, and K. Kojima Phosphorus Res. Bull., 19, 209-214 (2005).


List of 1996-2004


Go back to main page