業 績
論文発表
２０１４年度
1. Binding Properties of Antimicrobial Agents to Lipid Membranes Using Surface Plasmon Resonance. Kinouchi, H., Arimoto, H., Nishiguchi, K., Oka, M., Maki, H., Kitagawa, H., and Kaminori H. Biol. Pharm. Bull., 査読有, 37, 1383-1389, (2014)
2.
*Heparan Sulfate Containing Unsubstituted Glucosamine Residues: Biosynthesis and Heparanase Inhibitory Activity. Nadanaka, S., Purunomo, E., Takeda, N., Tamura, J., and Kitagawa, H. J. Biol. Chem., 査読有, 289, 15231-15243, (2014) Faculty of 1000
3. *Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis. Miyamoto, K., Tanaka, N., Moriguchi, K., Ueno, R., Kadomatsu, K., Kitagawa, H., and Kusunoki, S. Glycobiology, 査読有, 24, 469-475, (2014)
4. Binding properties of antimicrobial agents to dipeptide terminal of lipid II using surface Plasmon resonance. Kinouchi, H., Arimoto, H., Nishiguchi, K., Oka, M., Maki, H., Kitagawa, H., and Kamimori, H.
Anal. Biochem., 査読有, 452, 67-75. (2014)
5. *Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. Koike, T., Izumikawa, T., Sato, B., and Kitagawa, H. J. Biol. Chem., 査読有, 289, 6695-6708, (2014) Faculty of 1000
6. *Chondroitin sulfate is indispensable for pluripotency and differentiation of mouse embryonic stem cells. Izumikawa, T., Sato, B., and Kitagawa, H. Sci. Rep., 査読有, 4, 3701, (2014)
7. *EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis. Nadanaka, S., and Kitagawa, H. Matrix Biol., 査読有, 35, 18-24, (2014)
8. Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension. Miyagawa, K., and Emoto, N. Ther. Adv. Cardiovasc. Dis., 査読有, in press, (2014)
9. Utility of combining assessment of right ventricular function and right atrial remodeling as a prognostic factor for patients with pulmonary hypertension. Fukuda, Y., Tanaka, H., Motoji, Y., Ryo, K., Sawa, T., Imanishi, J., Miyoshi, T., Mochizuki, Y., Tatsumi, K., Matsumoto, K., Shinke, T., Emoto, N., and Hirata, K.I. Int. J. Cardiovasc. Imaging., 査読有, in press, (2014)
10. Japanese Respiratory Society Lung Disease Pulmonary Hypertension Study Group. Current trends in the management of pulmonary hypertension associated with respiratory disease in institutions approved by the Japanese Respiratory Society. Tanabe, N., Taniguchi, H., Tsujino, I., Sakamaki, F., Emoto, N., Kimura, H., Miyaji, K., Takamura, K., Hayashi, S., Hanaoka, M., and Tatsumi, K. Respir. Investig., 査読有, 52,167-72, (2014)
11. Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports : strategy for ASD with severe PAH. Taniguchi, Y., Emoto, N., Miyagawa, K., Nakayama, K., Kinutani, H., Tanaka, H., Shinke, T., Okada, K., Okita, Y., and Hirata, K.I. Heart Vessels., 査読有, 29, 282-5, (2014)
12. Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice. Nugrahaningsih, D.A., Emoto, N., Vignon-Zellweger, N., Purnomo, E., Yagi, K., Nakayama, K., Doi, M., Okamura, H., and Hirata, K. Hypertens. Res., 査読有, 37, 202-209, (2014)
13. Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: Potential roles of interleukin-6 and endothelin. Van Hung, T., Emoto, N., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Suzuki, Y., and Hirata, K.I. Life Sci., 査読有, in press, (2014)
14. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. Makino, K., Jinnin, M., Aoi, J., Kajihara, I., Makino, T., Fukushima, S., Sakai, K., Nakayama, K., Emoto, N., Yanagisawa, M., and Ihn, H. PLoS One., 査読有, 22, e97972, (2014)
15. Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice. Heiden, S., Vignon-Zellweger, N., Masuda, S., Yagi, K., Nakayama, K., Yanagisawa, M., and Emoto N. PLoS One., 査読有, 11, e88730, (2014)
16. Synthetic Routes towards Benzofuro[2,3-b]pyrroles and Benzofuro[2,3-b]indoles. Ito, Y., Ueda, M., and Miyata, O. Heterocycles, 査読有, in press, DOI: 10.3987/REV-14-798, (2014)
17. Direct Synthesis of Benzofuro[2,3-b]pyrroles through a Radical Addition/[3,3]-Sigmatropic Rearrangement/Cyclization/Lactamization Cascade. Ueda, M., Ito, Y., Kakiuchi, M., Shono, H., and Miyata, O. Chem. Eur. J., 査読有, 20, 6763-6770, (2014)
18. Sequential Radical Addition and Fischer-type Indolization Reactions of Conjugated Hydrazones for The Preparation of α-Alkylindole-3-acetic Acids. Ito, Y., Ueda, M., Matsuda, N., Nishida, Y., and Miyata, O. Heterocycles査読有, 89, 963-969, (2014)
19. Preparation of Cyclic β-Amino Acid Derivatives with Quaternary Carbon Center via a Radical Addition-Cyclization Sequence. Takeda, N., Ueda., Kajisa, S., Matsuno, K., Naito, T., and Miyata, O. Heterocycles査読有, 89, 143-169, (2014)
20. Characterization of Reconstituted High-Density Lipoprotein Particles Formed by Lipid Interactions with Human Serum Amyloid A. Takase, H., Furuchi, H., Tanaka, M., Yamada, T., Matoba, K., Iwasaki, K., Kawakami, T. and Mukai, T. Biochim. Biophys. Acta, 査読有, 1841, 1467-1474, (2014)
21. *Effect of Amino Acid Variations in the Central Region of Human Serum Amyloid A on the Amyloidogenic Properties. Takase, H., Tanaka, M., Miyagawa, S., Yamada, T., and Mukai, T. Biochem. Biophys. Res. Commun., 査読有, 444, 92-97, (2014)
２０１３年度
1. *Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury. Takeuchi, K., Yoshioka, N., Higa Onaga, S., Watanabe, Y., Miyata, S., Wada, Y., Kudo, C., Okada, M., Ohko, K., Oda, K., Sato, T., Yokoyama, M., Matsushita, N., Nakamura, M., Okano, H., Sakimura, K., Kawano, H., Kitagawa, H., and Igarashi, M. Nature Commun., 査読有, 4, 2740, (2013)
2. *Michael Addition-Aromatization Reaction of Dienylimines Bearing a Leaving Group and its Application to the Preparation of Thiol Selective Labeling Reagents Capable of Forming Strong Carbon-Sulfur Bonds. Miyoshi, T., Aoki, Y., Uno, Y., Araki, M., Kamatani, T., Fujii, D., Fujita, Y., Takeda, N., Ueda, M., Kitagawa, H., Emoto, N., Mukai, T., Tanaka, M., and Miyata, O. J. Org. Chem., 査読有, 78, 11433-11443, (2013)
3. *Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease. Purunomo, E., Emoto, N., Nugrahaningsih, D., Nakayama, K., Yagi, K., Heiden, S., Nadanaka, S., Kitagawa, H., and Hirata, K. J. Am. Heart Assoc., 査読有, 2, e000405, (2013)
4. *Roles of EXTL2, a member of EXT family of tumor suppressors, in liver injury and regeneration processes. Nadanaka, S., Kagiyama, S., and Kitagawa, H. Biochem. J., 査読有, 454(1), 133-145, (2013)
5. *A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1. Izumikawa, T., Saigoh, K., Shimizu, J., Tsuji, S., Kusunoki, S., and Kitagawa, H. Biochim. Biophys. Acta, 査読有, 1830, 4806-4812, (2013)
6. *EXTL2, a member of EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner. Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M., and Kitagawa, H. J. Biol. Chem., 査読有, 288, 9321-9333, (2013)
7. Nephrocalcinosis (Enamel Renal Syndrome) caused by autosomal recessive FAM20A mutations. Jaureguiberry, G., De la Dure-Molla, M., Parry, D., Quentric, M., Himmerkus, N., Koike, T., Poulter, J., Klootwijk, E., Robinette, S. L., Howie, A. J., Patel, V., Figueres, M. -L., Stanescu, H. C., Issler, N, Nicholson, J. K., Bockenhauer, D., Laing, C., Walsh, S. B., McCredie, D. A., Povey, S., Asselin, A, Picard, A., Coulomb, A., Medlar, A. J., Bailleul-Forestier, I., Verloes, A,. Le Caignec, C., Roussey, G., Guiol, J., Isidor, B., Logan, C., Shore, R., Johnson, C., Inglehearn, C., Al-Bahlani, S., Schmittbuhl, M., Clauss, F., Huckert, M., Laugel, V., Ginglinger, E., Pajarola, S., Sparta, G., Bartholdi, D., Rauch, A., Addor, M. -C., Yamaguti, P. M., Safatle, H. P., Acevedo, A. C., Martelli-Junior, H., dos Santos Netos, P. E., Coletta, R. D., Gruessel, S., Sandmann, C., Ruehmann, D., Langman, C. B., Scheinman, S. J., Ozdemir-Ozenen, D., Hart, T. C., Hart, P. S., Neugebauer, U., Schlatter, E., Houillier, P., Gahl, W. A., Vikkula, M., Bloch-Zupan, A., Bleich, M., Kitagawa, H., Unwin, R. J., Mighell, A., Berdal, A., and Kleta, R. Nephron. Physiol., 査読有, 122, 1-6, (2013)
8. *Biosynthesis and function of chondroitin sulfate. Mikami, T., and Kitagawa, H. Biochim. Biophys. Acta, 査読有, 1830, 4719-4733, (2013)
9. *Localization and Characterization of a Novel Secreted Protein, SCUBE2, in the Development and Progression of Atherosclerosis. Ali, H., Emoto, N., Yagi, K., Vignon-Zellweger, N., Nakayama, K., Hatakeyama, K., Asada, Y., Rikitake, Y., and Hirata, K. Kobe J. Med. Sci., 査読有, 59, E122-131, (2013)
10. Noninvasive and simple assessment of cardiac output and pulmonary vascular resistance with whole-body impedance cardiography is useful for monitoring patients with pulmonary hypertension. Taniguchi, Y., Emoto, N., Miyagawa, K., Nakayama, K., Kinutani, H., Tanaka, H., Shinke, T., and Hirata K. Circ. J., 査読有, 77, 2383-2389, (2013)
11. *Rhodamine-labeled LDL as a tool to monitor the lipoprotein traffic in experimental model of early atherosclerosis in mice. Mayasari, D.S., Emoto, N., Yagi, K., Vignon-Zellweger, N., Nakayama, K., Miyoshi, T., Miyata, O., and Hirata K. Kobe J Med Sci., 査読有, 59, E54-63, (2013)
12. Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis. Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., and Minami, Y. Genes Cells, 査読有, 18, 608-619, (2013)
13. Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports : Strategy for ASD with Severe PAH. Taniguchi, Y., Emoto, N., Miyagawa, K., Nakayama, K., Kinutani, H., Tanaka, H., Shinke, T., Okada, K., Okita, Y., and Hirata, K. Heart Vessels., 査読有, 29, 282-285, (2013)
14. Endothelin-converting enzyme-1 gene ablation attenuates pulmonary fibrosis via CGRP-cAMP/EPAC1 pathway. Hartopo, A.B., Emoto, N., Vignon-Zellweger, N., Suzuki, Y., Yagi, K., Nakayama, K., and Hirata, K. Am. J. Respir Cell. Mol. Biol., 査読有, 48, 465-476, (2013)
15. Efficacy of right ventricular free-wall longitudinal speckle-tracking strain for predicting long-term outcome in patients with pulmonary hypertension. Motoji, Y., Tanaka, H., Fukuda, Y., Ryo, K., Emoto, N., Kawai, H., Hirata, K. Circ. J., 査読有, 77, 756-763, (2013)
16. Total Synthesis of Penmacric Acids via an Intermolecular Radical Addition Reaction. Ueda, M., Ono, A., Nakao, D., Matsuno, K., Naito, T., and Miyata, O. Tetrahedron, 査読有, 69, 6866-6874, (2013)
17. Sequential Retro-Ene Arylation Reaction of N-Alkoxyenamides for the Synthesis of tert-Alkylamines. Miyoshi, T., Matsuya, S., Tsugawa, M., Sato, S., Ueda, M., and Miyata, O. Org. Lett., 査読有, 15, 3374-3377, (2013)
18. Synthesis of Dihydrobenzofurans with Quaternary Carbon Center under Mild and Neutral Conditions. Takeda, N., Ueda, M., Kagehira, S., Komei, H., Tohnai, N., Miyata, M., Naito, T., and Miyata, O. Org. Lett., 査読有, 15, 4382-4385, (2013)
19. Palladium-Catalyzed Synthesis of Isoquinolinones via Sequential Cyclization and N-O Bond Cleavage of N-Methoxy-o-alkynylbenzamides. Jithunsa, M., Ueda, M., Aoi, N., Sugita, S., Miyoshi, T, and Miyata, O. Synlett, 査読有, 475-478, (2013)
20. Umpolung reactions at the α-carbon position of carbonyl compounds. Miyata, O., Miyoshi, T., and Ueda, M. ARKIVOC, 査読有, 60-81, (2013)
２０１２年度
1. *Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies. Mikami, T., Koyama, S., Yabuta, Y., and Kitagawa, H. J. Biol. Chem., 査読有, 287, 38531-38542, (2012)
2. *Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadherin and cadherin-11. Koike, T., Izumikawa, T., Tamura, J., and Kitagawa, H. Biochem. Biophys. Res. Commun., 査読有, 420, 523-529, (2012)
3. Physiological relevance of hydrolysis of atrial natriuretic peptide by endothelin-converting enzyme-1. Nakayama, K., Emoto, N., Suzuki, Y., Vignon-Zellweger, N., Yagi, K., and Hirata, K. Kobe. J. Med. Sci., 査読有, 58, E12-8, (2012)
4. ET-1 deletion from endothelial cells protects the kidney during the extension phase of ischemia/reperfusion injury. Arfian, N., Emoto, N., Vignon-Zellweger, N., Nakayama, K., Yagi, K., and Hirata, K. Biochem. Biophys. Res. Commun., 査読有, 425, 443-449, (2012)
5. Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER). Satomi-Kobayashi, S., Kinugasa, M., Kobayashi, R., Hatakeyama, K., Kurogane, Y., Ishida, T., Emoto, N., Asada, Y., Takai, Y., Hirata, K., and Rikitake, Y. J. Biol. Chem., 査読有, 287, 30336-30345, (2012)
6. ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy. Adiarto, S., Heiden, S., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Yanagisawa, M., and Emoto, N. Life Sci., 査読有, 91, 651-657, (2012)
7. Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis. Tawaramoto, K., Kotani, K., Hashiramoto, M., Kanda, Y., Nagare, T., Sakaue, H., Ogawa, W., Emoto, N., Yanagisawa, M., Noda, T., Kasuga, M., and Kaku, K. Mol. Endocrinol., 査読有, 26, 95-109, (2012)
8. Endothelin and endothelin receptors in the renal and cardiovascular systems. Vignon-Zellweger, N., Heiden, S., Miyauchi, T., and Emoto, N. Life Sci., 査読有, 91, 490-500, (2012)
9. One-pot method for α-phenylation of ketones using isoxazolidine and triphenylaluminum. Miyoshi, T., Sato, S., Tanaka, H., Hasegawa, C., Ueda, M., and Miyata, O. Tetrahedron Lett., 査読有, 53, 4188-4191, (2012)
10. Copper-Catalyzed Synthesis of Trisubstituted Isoxazoles via a Cascade Cyclization. Ueda, M., Sugita, S., Sato, A., Miyoshi, T., and Miyata, O. J. Org. Chem., 査読有, 77, 9344-9351, (2012)