2017

  • Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, Yamashita T. (2017) Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 127(9):3496-3509. doi: 10.1172/JCI94337. link

  • Yamaki K., Ikeda K., Ueda K., Habu Y., Nakayama Y., Takeda N., Moriwaki K., Wada A., Koyama J., Kodama N., Kitagawa S. (2017) Enhancing Study Motivation and Efficacy among First-Year Students Using Minute Papers in the Interdisciplinary Subject of Yakugaku Nyumon. Yakugaku Zasshi. 137(10):1285-1299. doi: 10.1248/yakushi.17-00035. link

  • Kasubuchi M, Watanabe K, Hirano K, Inoue D, Li X, Terasawa K, Konishi M, Itoh N, and Kimura I. (2017) Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling. Sci Rep. 12;7(1):5168. doi: 10.1038/s41598-017-05423-9. link

  • Miyake A., Mekata Y, Fujibayashi H, Nakanishi K, Konishi M, Itoh N. (2017) Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. PLoS One. 12(4):e0176036. doi: 10.1371/journal.pone.0176036. link

  • Nakayama Y., Masuda Y., Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M. (2017) Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci. Rep. 23:7(1):330. doi: 10.1038/s41598-017-00349-8. link

  • Masuda Y, Nakayama Y, Tanaka A, Naito K, Konishi M. (2017) Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor. PLoS One. 12(3):e0173621. doi: 10.1371/journal.pone.0173621. link

  • 2016

  • Itoh N., Nakayama Y., Konishi M. (2016) Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease Front. Cell Dev. Biol. 4:30. doi: 10.3389/fcell.2016.00030 link

  • Konishi M., Nakayama Y., Masuda Y. (2016) Secreted factor, FGF21, regulates diverse biological processes. Seikagaku. 88(1):86-93.  PubMed

  • Yamaki K., Ueda M., Ueda K., Emoto N., Mizutani N., Ikeda K., Yagi K., Tanaka M., Habu Y., Nakayama Y., Takeda N., Moriwaki K., Kitagawa S. (2016) Interdisciplinary Subject “YakugakuNyumon” for First-Year Students Constructed with Lectures and Problem-Based Learning. Yakugaku Zasshi. 136(7):1051-64. doi: 10.1248/yakushi.15-00255. 

  • 2015

  • Ozaki Y., Saito K., Nakazawa K., Konishi M., Itoh N., Hakuno F., Takahashi S., Kato H., Takenaka A. (2015) Rapid increase of fibroblast growth factor 21 under protein malnutrition and its impact on growth and lipid metabolism. Br J Nutr. 10;116:101-4. doi: 10.1016/j.jpba.2015.04.028. PubMed

  • Masuda Y., Nawa D., Nakayama Y., Konishi M., Nanba H. (2015) Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity. J Leukoc Biol. 98(6):1015-25. doi: 10.1189/jlb.1A0814-415RR. PubMed

  • Ohta H., Kimura I., Konishi M., Itoh N. (2015) Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis. Front Mol Biosci. 19;2:24. doi: 10.3389/fmolb.2015.00024. PubMed

  • Kato S., Masuda Y., Konishi M., Oikawa T. (2015) Enantioselective analysis of D- and L-amino acids from mouse macrophages using high performance liquid chromatography. J Pharm Biomed Anal. 116:101-4.doi: 10.1016/j.jpba.2015.04.028. PubMed

  • Ohta H., Konishi M., Kobayashi Y., Kashio A., Mochiyama T., Matsumura S., Inoue K., Fushiki T., Nakao K., Kimura I., Itoh N. (2015) Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity. Sci Rep. 5:10049. doi: 10.1038/srep10049. PubMed

  • Masuda Y., Ohta Y, Morita Y, Nakayama Y, Miyake A, Itoh N, Konishi M. (2015) Expression of Fgf23 in activated dendritic cells and macrophages in response to immunological stimuli in mice. Biol Pharm Bull. 38(5):687-93 PubMed

  • Kim SH, Kim KH, Kim HK, Kim MJ, Back SH, Konishi M, Itoh N, Lee MS. (2015) Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress. Diabetologia 58(4):809-18 PubMed

  • Itho N., Ohta H., Konishi M. (2015) Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy. Front Endocrinol. 6:154. doi: 10.3389/fendo.2015.00154. PubMed

  • 2014

  • Miyake A, Chitose T, Kamei E, Murakami A, Nakayama Y, Konishi M, Itoh N. (2014) Fgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain. PLoS One 9(10):e110836 PubMed


  • 2013

  • Murata Y, Nishio K, Mochiyama T, Konishi M, Shimada M, Ohta H, Itoh N. (2013) Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet. PLoS One Jul 9;8(7):e69330 PubMed

  • Kimura I, Nakayama Y, Zhao Y, Konishi M, Itoh N. (2013) Neurotrophic effects of neudesin in the central nervous system. Front Neurosci 7:111 PubMed

  • Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A, Li X. (2013) Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab May 7;17(5):779-89 PubMed

  • Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N. (2013) Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. Genes Cells Jul;18(7):544-53 PubMed

  • Habegger KM, Stemmer K, Cheng C, Muller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, et al. (2013) Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes May;62(5):1453-63 PubMed

  • Masuda Y, Inoue H, Ohta H, Miyake A, Konishi M, Nanba H. (2013) Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice. Int J Cancer Jul;133(1):108-19 PubMed

  • Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim do H, Hur KY, Kim HK, Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS. (2013) Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med Jan;19(1):83-92 PubMed


  • 2012

  • Kimura I, Nakayama Y, Konishi M, Terasawa K, Ohta M, Itoh N, Fujimoto M. (2012) Functions of MAPR (membrane-associated progesterone receptor) family members as heme/steroid-binding proteins. Curr Protein Pept Sci Nov;13(7):687-96 PubMed

  • Masuda Y, Togo T, Mizuno S, Konishi M, Nanba H. (2012) Soluble β-glucan from Grifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway. J Leukoc Biol Apr;91(4):547-56 PubMed


  • 2011

  • Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A. (2011) Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. J Biol Chem Oct 7;286(40):34559-66 PubMed

  • Oishi K, Konishi M, Murata Y, Itoh N. (2011) Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice. Biochem Biophys Res Commun Aug 26;412(2):396-400 PubMed

  • Konishi M, Itoh N. (2011) [FGF21]. Nihon Rinsho Jan;69 Suppl 1:336-40 PubMed

  • Ohta H, Konishi M, Itoh N. (2011) FGF10 and FGF21 as regulators in adipocyte development and metabolism. Endocr Metab Immune Disord Drug Targets Dec;11(4):302-9 PubMed

  • Murata Y, Konishi M, Itoh N. (2011) FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology. J Nutr Metab 2011:981315 PubMed


  • 2010

  • Masuda Y, Ito K, Konishi M, Nanba H. (2010) A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunol Immunother Oct;59(10):1531-41 PubMed

  • Oishi K, Sakamoto K, Konishi M, Murata Y, Itoh N, Sei H. (2010) FGF21 is dispensable for hypothermia induced by fasting in mice. Neuro Endocrinol Lett 31(2):198-202 PubMed

  • Kimura I, Nakayama Y, Konishi M, Kobayashi T, Mori M, Ito M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M. (2010) Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis. J Neurochem Mar;112(5):1156-67 PubMed


  • 2009以前

  • Miyake A, Takahashi Y, Miwa H, Shimada A, Konishi M, Itoh N. (2009) Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Biochem Biophys Res Commun Dec 18;390(3):1051-5 PubMed

  • Miwa H, Miyake A, Kouta Y, Shimada A, Yamashita Y, Nakayama Y, Yamauchi H, Konishi M, Itoh N. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett Nov 19;583(22):3643-8 PubMed

  • Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, Inoue K, Fushiki T, Itoh N. (2009) Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology Oct;150(10):4625-33 PubMed

  • Kimura I, Konishi M, Asaki T, Furukawa N, Ukai K, Mori M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M. (2009) Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade. Biochem Biophys Res Commun Mar 27;381(1):75-80 PubMed

  • Masuda Y, Matsumoto A, Toida T, Oikawa T, Ito K, Nanba H. (2009) Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa. J Agric Food Chem Nov 11;57(21):10143-9 PubMed

  • Ito K, Masuda Y, Yamasaki Y, Yokota Y, Nanba H. (2009) Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression. Int Immunopharmacol Sep;9(10):1189-96 PubMed

  • Masuda Y, Inoue M, Miyata A, Mizuno S, Nanba H. (2009) Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin inmice. Int Immunopharmacol May;9(5):620-6 PubMed

  • Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, Itoh N. (2008) Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Dev Dyn Oct;237(10):2947-54 PubMed

  • Konishi M, Nakamura H, Miwa H, Chambon P, Ornitz DM, Itoh N. (2008) Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue. Mol Cell Endocrinol Jun 11;287(1-2):13-9 PubMed

  • Nakayama Y, Miyake A, Nakagawa Y, Mido T, Yoshikawa M, Konishi M, Itoh N. (2008) Fgf19 is required for zebrafish lens and retina development. Dev Biol Jan 15;313(2):752-66 PubMed

  • Kimura I, Nakayama Y, Yamauchi H, Konishi M, Miyake A, Mori M, Ohta M, Itoh N, Fujimoto M. (2008) Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain. J Biol Chem Feb 15;283(7):4323-31 PubMed

  • Masuda Y, Murata Y, Hayashi M, Nanba H. (2008) Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells. Biol Pharm Bull Jun;31(6):1104-8 PubMed

  • Itoh N, Konishi M. (2007) The zebrafish fgf family. Zebrafish Fall;4(3):179-86 PubMed

  • Koike N, Kassai Y, Kouta Y, Miwa H, Konishi M, Itoh N. (2007) Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. J Biol Chem May 25;282(21):15843-50 PubMed

  • Wakahara T, Kusu N, Yamauchi H, Kimura I, Konishi M, Miyake A, Itoh N. (2007) Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. Dev Biol Mar 15;303(2):527-35 PubMed

  • Nomura R, Kamei E, Hotta Y, Konishi M, Miyake A, Itoh N. (2006) Fgf16 is essential for pectoral fin bud formation in zebrafish. Biochem Biophys Res Commun Aug 18;347(1):340-6 PubMed

  • Yamauchi H, Hotta Y, Konishi M, Miyake A, Kawahara A, Itoh N. (2006) Fgf21 is essential for haematopoiesis in zebrafish. EMBO Rep Jun;7(6):649-54 PubMed

  • Kimura I, Konishi M, Miyake A, Fujimoto M, Itoh N. (2006) Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells. J Neurosci Res Jun;83(8):1415-24 PubMed

  • Konishi M, Asaki T, Koike N, Miwa H, Miyake A, Itoh N. (2006) Role of Fgf10 in cell proliferation in white adipose tissue. Mol Cell Endocrinol Apr 25;249(1-2):71-7 PubMed

  • Miyake A, Nakayama Y, Konishi M, Itoh N. (2005) Fgf19 regulated by Hh signaling is required for zebrafish forebrain development. Dev Biol Dec 1;288(1):259-75 PubMed

  • Nakamura N, Toba S, Hirai M, Morishita S, Mikami T, Konishi M, Itoh N, Kurosaka A. (2005) Cloning and expression of a brain-specific putative UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase gene. Biol Pharm Bull Mar;28(3):429-33 PubMed

  • Kimura I, Yoshioka M, Konishi M, Miyake A, Itoh N. (2005) Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. J Neurosci Res Feb 1;79(3):287-94 PubMed

  • Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H. (2005) Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncol Rep Mar;13(3):497-502 PubMed

  • Usui H, Shibayama M, Ohbayashi N, Konishi M, Takada S, Itoh N. (2004) Fgf18 is required for embryonic lung alveolar development. Biochem Biophys Res Commun Sep 24;322(3):887-92 PubMed

  • Asaki T, Konishi M, Miyake A, Kato S, Tomizawa M, Itoh N. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol Cell Endocrinol Apr 15;218(1-2):119-28 PubMed

  • Ohmachi S, Mikami T, Konishi M, Miyake A, Itoh N. (2003) Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c. J Neurosci Res May 15;72(4):436-43 PubMed

  • Kusu N, Laurikkala J, Imanishi M, Usui H, Konishi M, Miyake A, Thesleff I, Itoh N. (2003) Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J Biol Chem Jun 27;278(26):24113-7 PubMed

  • Hoshikawa M, Yonamine A, Konishi M, Itoh N. (2002) FGF-18 is a neuron-derived glial cell growth factor expressed in the rat brain during early postnatal development. Brain Res Mol Brain Res Sep 30;105(1-2):60-6 PubMed

  • Yamashita T, Konishi M, Miyake A, Inui K, Itoh N. (2002) Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway. J Biol Chem Aug 2;277(31):28265-70 PubMed

  • Sakaue H, Konishi M, Ogawa W, Asaki T, Mori T, Yamasaki M, Takata M, Ueno H, Kato S, Kasuga M, Itoh N. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev Apr 15;16(8):908-12 PubMed