英文原書

2023年

Musthafa A, Ryanto GRT, Suraya R, Nagano T, Suzuki Y, Hara T, Hirata KI, Emoto N.　Acute Amelioration of Inflammatory Activity Caused by Endothelin-2 Deficiency during Acute Lung Injury.
Kobe J Med Sci. (2023) Oct 24;69(3):E96-E105. doi: 10.24546/0100483406.

Horibe S, Emoto T, Mizoguchi T, Tanaka T, Kawauchi S, Sasaki N, Yamashita T, Ikeda K, Emoto N, Hirata KI, Rikitake Y. Endothelial senescence alleviates cognitive impairment in a mouse model of Alzheimer's disease.
Glia. (2024) Jan;72(1):51-68. doi: 10.1002/glia.24461. Epub 2023 Aug 23.

Hadwiono MR, Hartopo AB, Wasityastuti W, Anggrahini DW, Ryanto GRT, Emoto N, Dinarti LK. Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry.
Pulm Circ. (2023) Aug 21;13(3):e12280. doi: 10.1002/pul2.12280. eCollection 2023 Jul.

Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, Yari S, Sato T, Kamakura T, Oshima K, Imai R, Liu YC, Okuzaki D, Hara T, Motooka D, Emoto N, Inohara H, Ishii M. Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction.
Nat Commun. (2023) Aug 3;14(1):4417. doi: 10.1038/s41467-023-40094-3.

Murni IK, Kato T, Wirawan MT, Arafuri N, Hermawan K, Hartopo AB, Anggrahini DW, Nugroho S, Noormanto N, Emoto N, Dinarti LK. An electrocardiographic score to predict pulmonary hypertension in children with atrial septal defect.
BMC Pediatr. (2023) Jun 10;23(1):288. doi: 10.1186/s12887-023-04102-1.

Ramadhiani R, Ikeda K, Miyagawa K, Ryanto GRT, Tamada N, Suzuki Y, Kirita Y, Matoba S, Hirata KI, Emoto N. Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells.
iScience. (2023) Apr 11;26(5):106662. doi: 10.1016/j.isci.2023.106662. eCollection 2023 May 19.

Ryanto GRT, Musthafa A, Hara T, Emoto N. Inactivating the Uninhibited: The Tale of Activins and Inhibins in Pulmonary Arterial Hypertension. Int J Mol Sci. (2023) Feb 7;24(4):3332. doi: 10.3390/ijms24043332.

Yoneda K, Takahashi S, Nakayama K, Iwahashi M, Emoto N, Kumagai S. Combination of echocardiography and pulmonary function tests could predict no complication of pulmonary hypertension during 5 years in patients with systemic sclerosis. Int J Rheum Dis. (2023) Feb 3. doi: 10.1111/1756-185X.14576. Online ahead of print.

Fujii H, Taniguchi Y, Yoneda S, Miwa K, Matsuoka Y, Yanaka K, Tsuboi Y, Emoto N, Hirata K. Efficacy and Safety of Balloon Pulmonary Angioplasty for Patients With Chronic Thromboembolic Pulmonary Hypertension and Comorbid Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. (2023) Feb 7;12(3):e026466. doi: 10.1161/JAHA.122.026466. Epub 2023 Feb 3.

Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu YC, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M. In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nat Commun. (2023) Jan 17;14(1):143. doi: 10.1038/s41467-022-35701-8.

Kawauchi S, Mizoguchi T, Horibe S, Tanaka T, Sasaki N, Ikeda K, Emoto N, Hirata KI, Rikitake Y. Gliovascular interface abnormality in mice with endothelial cell senescence. Glia. (2023) Feb;71(2):467-479. doi: 10.1002/glia.24287. Epub 2022 Oct 26.

2022年

Hartopo AB, Anggrahini DW, Satwiko MG, Damarkusuma A, Pritazahra A, Hadwiono MR, Dewanto VC, Di Somma S, Emoto N, Dinarti LK. Usefulness of Combining NT-proBNP Level and Right Atrial Diameter for Simple and Early Noninvasive Detection of Pulmonary Hypertension Among Adult Patients with Atrial Septal Defect. Acta Med Indones. (2022) Oct;54(4):556-566.

Miwa K, Taniguchi Y, Fujii H, Matsuoka Y, Onishi H, Yanaka K, Izawa Y, Tsuboi Y, Kono A, Emoto N, Hirata K. Microvasculopathy Evaluated by Dual-Energy Computed Tomography in Patients with Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension. Life (Basel). (2022) Aug 15;12(8):1232. doi: 10.3390/life12081232.

Suraya R, Nagano T, Ryanto GRT, Effendi WI, Hazama D, Katsurada N, Yamamoto M, Tachihara M, Emoto N, Nishimura Y, Kobayashi K. Budesonide/glycopyrronium/formoterol fumarate triple therapy prevents pulmonary hypertension in a COPD mouse model via NFκB inactivation. Respir Res. (2022) Jun 27;23(1):173. doi: 10.1186/s12931-022-02081-y.

Suprapto RP, Suzuki Y, Nagano T, Hirata KI, Emoto N. The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line. Can J Physiol Pharmacol. (2022) Aug 1;100(8):818-827. doi: 10.1139/cjpp-2022-0006. Epub 2022 Jun 9.

Haryono A, Ramadhiani R, Ryanto GRT, Emoto N. Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going. Biology (Basel). (2022) May 16;11(5):759. doi: 10.3390/biology11050759.

Yanaka K, Nakayama K, Taniguchi Y, Onishi H, Matsuoka Y, Nakai H, Okada K, Shinke T, Emoto N, Hirata KI. RC time (resistance × compliance) is related to residual symptom after pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. Int J Cardiol Heart Vasc. (2022) Apr 18;40:101031. doi: 10.1016/j.ijcha.2022.101031. eCollection 2022 Jun.

Haryono A, Ikeda K, Nugroho DB, Ogata T, Tsuji Y, Matoba S, Moriwaki K, Kitagawa H, Igarashi M, Hirata KI, Emoto N. ChGn-2 Plays a Cardioprotective Role in Heart Failure Caused by Acute Pressure Overload. J Am Heart Assoc. (2022) Apr 5;11(7):e023401. doi: 10.1161/JAHA.121.023401. Epub 2022 Mar 24.

2021年

Ramadhiani R, Ikeda K, Hirata KI, Emoto N. Endothelial Cell Senescence Exacerbates Pulmonary Fibrosis Potentially Through Accelerated Endothelial to Mesenchymal Transition. Kobe J Med Sci. (2021) Nov 2;67(3):E84-E91.

Sumimoto K, Taniguchi Y, Emoto N, Hirata KI. A rare case of intimal sarcoma mimicking pulmonary stenosis. Eur Heart J Case Rep. (2021) Nov 4;5(11):ytab440. doi: 10.1093/ehjcr/ytab440. eCollection 2021 Nov.

Soraya AI, Suzuki Y, Morimoto M, Ko CJ, Ikeda K, Hirata KI, Emoto N. Protective Effects of Endothelin-2 Expressed in Epithelial Cells on Bleomycin-Induced Pulmonary Fibrosis in Mice. Kobe J Med Sci. (2021) Nov 2;67(2):E61-E70.

Prabata A, Ikeda K, Rahardini EP, Hirata KI, Emoto N. GPNMB plays a protective role against obesity-related metabolic disorders by reducing macrophage inflammatory capacity. J Biol Chem. (2021) Nov 297(5):101232. doi: 10.1016/j.jbc.2021.101232. Epub 2021 Sep 25.

Sumimoto K, Taniguchi Y, Fujii H, Miwa K, Matsuoka Y, Tsuboi Y, Emoto N, Hirata KI. Rescue balloon pulmonary angioplasty for life-threatening acute pulmonary embolism on chronic thromboembolic pulmonary hypertension patients. Respir Med Case Rep. (2021) Apr 13;33:101415. doi: 10.1016/j.rmcr.2021.101415. eCollection 2021.

Honda S, Ikeda K, Urata R, Yamazaki E, Emoto N, Matoba S. Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis. Sci Rep. (2021) Jul 16;11(1):14608. doi: 10.1038/s41598-021-94097-5.

Shima A, Maki T, Mimura N, Yamashita H, Emoto N, Yoshifuji H, Takahashi R. A case of reversible cerebral vasoconstriction syndrome associated with anti-phospholipid antibody syndrome and systemic lupus erythematosus. eNeurologicalSci. (2021) Jun 16;24:100351. doi: 10.1016/j.ensci.2021.100351. eCollection 2021 Sep.

Matsuoka Y, Taniguchi Y, Miwa K, Sumimoto K, Tsuboi Y, Onishi H, Yanaka K, Emoto N, Hirata K. Reply to to the editor, in response to: Assessment of oxygenation after balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension. Int J Cardiol. (2021) Sep 1;338:237. doi: 10.1016/j.ijcard.2021.06.008. Epub 2021 Jun 9.

Takami M, Hara T, Okimoto T, Suga M, Fukuzawa K, Kiuchi K, Suehiro H, Akita T, Takemoto M, Nakamura T, Sakai J, Yatomi A, Nakasone K, Sonoda Y, Yamamoto K, Takahara H, Hirata KI. Electrophysiological and Pathological Impact of Medium-Dose External Carbon Ion and Proton Beam Radiation on the Left Ventricle in an Animal Model. J Am Heart Assoc. (2021) Apr 6;10(7):e019687. doi: 10.1161/JAHA.120.019687. Epub 2021 Mar 24.

Ryanto GRT, Ikeda K, Miyagawa K, Tu L, Guignabert C, Humbert M, Fujiyama T, Yanagisawa M, Hirata KI, Emoto N. An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension. Nat Commun. (2021) Mar >19;12(1):1720. doi: 10.1038/s41467-021-21961-3.

Matsuoka Y, Taniguchi Y, Miwa K, Sumimoto K, Tsuboi Y, Onishi H, Yanaka K, Emoto N, Hirata K. Assessment of oxygenation after balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension. Int J Cardiol. (2021) Jun 15;333:188-194. doi: 10.1016/j.ijcard.2021.03.002. Epub 2021 Mar 6.

Tanabe N, Kumamaru H, Tamura Y, Taniguchi H, Emoto N, Yamada Y, Nishiyama O, Tsujino I, Kuraishi H, Nishimura Y, Kimura H, Inoue Y, Morio Y, Nakatsumi Y, Satoh T, Hanaoka M, Kusaka K, Sumitani M, Handa T, Sakao S, Kimura T, Kondoh Y, Nakayama K, Tanaka K, Ohira H, Nishimura M, Miyata H, Tatsumi K; JRPHS Group. Multi-Institutional Prospective Cohort Study of Patients With Pulmonary Hypertension Associated With Respiratory Diseases. Circ J. (2021) Mar 25;85(4):333-342. doi: 10.1253/circj.CJ-20-0939. Epub 2021 Feb 2.

Onishi H, Taniguchi Y, Matsuoka Y, Yanaka K, Izawa Y, Tsuboi Y, Mori S, Kono A, Nakayama K, Emoto N, Hirata KI. Evaluation of microvasculopathy using dual-energy computed tomography in patients with chronic thromboembolic pulmonary hypertension. Pulm Circ. (2021) Jan 20;11(1):2045894020983162. doi: 10.1177/2045894020983162. eCollection 2021 Jan-Mar.

Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata KI, Emoto N. Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain. Arterioscler Thromb Vasc Biol. (2021) Mar;41(3):1076-1091. doi: 10.1161/ATVBAHA.120.315789. Epub 2021 Jan 28.

Taniguchi Y, Matsuoka Y, Onishi H, Yanaka K, Emoto N, Nakai H, Okada K, Hirata K. The role of balloon pulmonary angioplasty and pulmonary endarterectomy: Is chronic thromboembolic pulmonary hypertension still a life-threatening disease? Int J Cardiol. (2021) Mar 1;326:170-177. doi: 10.1016/j.ijcard.2020.10.026. Epub 2020 Oct 18.

Nakayama K, Nakajima Y, Tanaka R, Hirata KI, Emoto N. Predictors of Long-term Outcomes in Patients With Connective Tissue Disease Associated With Pulmonary Arterial Hypertension. J Clin Rheumatol. (2021) Dec 1;27(8):e371-e377. doi: 10.1097/RHU.0000000000001447.

2020年

Sumimoto K, Taniguchi Y, Emoto N, Hirata KI. Combination therapy with pulmonary arterial hypertension targeted drugs and immunosuppression can be a useful strategy for sarcoidosis-associated pulmonary hypertension: a case report. Eur Heart J Case Rep. (2020) Dec 16;5(1):ytaa454. doi: 10.1093/ehjcr/ytaa454. eCollection 2021 Jan.

Taniguchi Y, Matsuoka Y, Onishi H, Yanaka K, Emoto N, Nakai H, Okada K, Hirata K. The role of balloon pulmonary angioplasty and pulmonary endarterectomy: Is chronic thromboembolic pulmonary hypertension still a life-threatening disease? Int J Cardiol. (2020):S0167-5273(20)33979-6. doi: 10.1016/j.ijcard.2020.10.026.

Arfian N, Suzuki Y, Hartopo AB, Anggorowati N, Nugrahaningsih DAA, Emoto N. Endothelin converting enzyme-1 (ECE-1) deletion in association with Endothelin-1 downregulation ameliorates kidney fibrosis in mice. Life Sci. (2020) Oct 1;258:118223. doi: 10.1016/j.lfs.2020.118223.

Nakayama K, Nakajima Y, Tanaka R, Hirata KI, Emoto N. Predictors of Long-term Outcomes in Patients With Connective Tissue Disease Associated With Pulmonary Arterial Hypertension. J Clin Rheumatol. (2020) doi: 10.1097/RHU.0000000000001447.

Yorifuji K, Uemura Y, Horibata S, Tsuji G, Suzuki Y, Nakayama K, Hatae T, Kumagai S, Emoto N. Predictive Model of Bosentan-Induced Liver Toxicity in Japanese Patients With Pulmonary Arterial Hypertension. Can J Physiol Pharmacol. (2020) doi: 10.1139/cjpp-2019-0656.

Ryanto GRT, Yorifuji K, Ikeda K, Emoto N. Chondroitin Sulfate Mediates Liver Responses to Injury Induced by Dual Endothelin Receptor Inhibition. Can J Physiol Pharmacol. (2020) doi: 10.1139/cjpp-2019-0649.

Mukai J, Tanaka H, Sano H, Yokota S, Suto M, Takada H, Soga F, Hatani Y, Matsuzoe H, Hatazawa K, Matsumoto K, Nakayama K, Emoto N, Hirata KI. Associations Between Functional Tricuspid Regurgitation and Long-Term Outcomes for Patients With Pulmonary Hypertension. Int J Cardiovasc Imaging. (2020) 36: 1261-1269. doi: 10.1007/s10554-020-01824-6.

Sumimoto K, Tanaka H, Mukai J, Yamashita K, Tanaka Y, Shono A, Suzuki M, Yokota S, Suto M, Takada H, Matsumoto K, Taniguchi Y, Emoto N, Hirata KI. Effects of Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension on Remodeling in Right-Sided Heart. Int J Cardiovasc Imaging. (2020) 36: 1053-1060. doi: 10.1007/s10554-020-01798-5.

Rinastiti P, Ikeda K, Rahardini EP, Miyagawa K, Tamada N, Kuribayashi Y, Hirata KI, Emoto N. Loss of Family With Sequence Similarity 13, Member A Exacerbates Pulmonary Hypertension Through Accelerating Endothelial-To-Mesenchymal Transition. PLoS One. (2020) 5(2): e0226049. doi: 10.1371/journal.pone.0226049.

Rahardini EP, Ikeda K, Nugroho DB, Hirata KI, Emoto N. Loss of Family With Sequence Similarity 13, Member A Exacerbates Pulmonary Fibrosis Potentially by Promoting Epithelial to Mesenchymal Transition. Kobe J Med Sci. (2020) 65: E100-E109.

Barinda AJ, Ikeda K, Nugroho DB, Wardhana DA, Sasaki N, Honda S, Urata R, Matoba S, Hirata KI, Emoto N. Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype. Nat Commun. (2020) 11: 481. doi: 10.1038/s41467-020-14387-w.

2019年

Hartopo AB, Anggrahini DW, Nurdiati DS, Emoto N, Dinarti LK. Severe pulmonary hypertension and reduced right ventricle systolic function associated with maternal mortality in pregnant uncorrected congenital heart diseases. Pulm Circ. (2019) 9: 2045894019884516.

Sari DCR, Arfian N, Tranggono U, Setyaningsih WAW, Romi MM, Emoto N. Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats. Iran J Basic Med Sci.(2019)10:1218-1224.

Severe pulmonary hypertension and reduced right ventricle systolic function associated with maternal mortality in pregnant uncorrected congenital heart diseases. Hartopo AB, Anggrahini DW, Nurdiati DS, Emoto N, Dinarti LK. Pulm Circ. 2019 Nov 18;9(4):2045894019884516. doi: 10.1177/2045894019884516. eCollection 2019 Oct-Dec.

Sumimoto K, Taniguchi Y, Matsuoka Y, Onishi H, Emoto N, Hirata KI. Anagrelide-induced pulmonary arterial hypertension": a rare case of drug-induced pulmonary arterial hypertension. Pulm Circ. (2019) 9(4):2045894019896682.

Suto M, Matsumoto K, Kido S, Mori S, Nakayama K, Tanaka H, Inoue T, Emoto N, Okita Y, Hirata KI. Advanced Pulmonary Hypertension Due to Congenital Double-shunt Successfully Treated with Surgical Repair and Up-front Combination Therapy. Intern Med. (2019) 58(9):1301-1305.

Yamasaki G, Okano M, Nakayama K, Jimbo N, Sendo S, Tamada N, Misaki K, Shinkura Y, Yanaka K, Tanaka H, Akashi K, Morinobu A, Yokozaki H, Emoto N, Hirata KI. Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis. Intern Med. (2019);58(4):593-601.

Adhikara IM, Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata KI, Emoto N. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. Biochem Biophys Res Commun. (2019) 509:89-95.

2018年

Sano H, Tanaka H, Motoji Y, Mukai J, Suto M, Takada H, Soga F, Hatani Y, Matsuzoe H, Hatazawa K, Shimoura H, Ooka J, Nakayama K, Matsumoto K, Yamada H, Emoto N, Hirata KI. Echocardiography during preload stress for evaluation of right ventricular contractile reserve and exercise capacity in pulmonary hypertension. Echocardiography. (2018) 35:1997-2004.

Yorifuji K, Uemura Y, Horibata S, Tsuji G, Suzuki Y, Miyagawa K, Nakayama K, Hirata KI, Kumagai S, Emoto N. Corrigendum to "CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension. Pharmacol. Res. (2018) S1043-6618(18)31413-0.

Nugroho DB, Ikeda K, Kajimoto K, Hirata KI, Emoto N. Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis. Biochem Biophys Res Commun. (2018) 504:427-433.

Nakayama K, Emoto N, Tamada N, Okano M, Shinkura Y, Yanaka K, Onishi H, Hiraishi M, Yamada S, Tanaka H, Shinke T, Hirata KI. The optimization of iloprost inhalation under moderate flow of oxygen therapy in severe pulmonary arterial hypertension. Pulm Circ. (2018) 8:2045894018781537.

Nugroho DB, Ikeda K, Barinda AJ, Wardhana DA, Yagi K, Miyata K, Oike Y, Hirata KI, Emoto N. Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature. Biochem Biophys Res Commun. (2018) 503:378-384.

Yorifuji K, Uemura Y, Horibata S, Tsuji G, Suzuki Y, Miyagawa K, Nakayama K, Hirata KI, Kumagai S, Emoto N. CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension. Pharmacol Res. (2018) 135:259-264.

Okano M, Nakayama K, Tamada N, Shinkura Y, Yanaka KI, Onishi H, Tanaka H, Shinke T, Tanaka H, Okita Y, Emoto N, Hirata KI. Reversible Parkinsonism and Multiple Cerebral Infarctions after Pulmonary Endarterectomy in a Patient with Antiphospholipid Syndrome. Intern Med. (2018) 57:2019-2023.

Qurania KR, Ikeda K, Wardhana DA, Barinda AJ, Nugroho DB, Kuribayashi Y, Rahardini EP, Rinastiti P, Ryanto GRT, Yagi K, Hirata KI, Emoto N. Systemic inhibition of Janus kinase induces browning of white adipose tissue and ameliorates obesity-related metabolic disorders. Biochem Biophys Res Commun. (2018) 502:123-128.

Hartopo AB, Arfian N, Nakayama K, Suzuki Y, Yagi K, Emoto N. Endothelial-derived endothelin-1 promotes pulmonary vascular remodeling in bleomycin-induced pulmonary fibrosis. Physiol Res. (2018) 67(Supplementum 1):S185-S197.

Arfian N, Kusuma MH, Anggorowati N, Nugroho DB, Jeffilano A, Suzuki Y, Ikeda K, Emoto N. Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice. Physiol Res. (2018) 67(Supplementum 1):S137-S147.

Yanaka K, Nakayama K, Shinke T, Shinkura Y, Taniguchi Y, Kinutani H, Tamada N, Onishi H, Tsuboi Y, Satomi-Kobayashi S, Otake H, Tanaka H, Okita Y, Emoto N, Hirata KI. Sequential Hybrid Therapy With Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. J Am Heart Assoc. (2018) 7:e008838.

Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Tsuboi Y, Izawa KP, Satomi-Kobayashi S, Otake H, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata KI. Early Introduction of Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension. JACC Cardiovasc Interv. (2018) 11:1114-1116.

Shinkura Y, Nakayama K, Yanaka K, Kinutani H, Tamada N, Tsuboi Y, Satomi-Kobayashi S, Otake H, Shinke T, Emoto N, Hirata KI. Extensive revascularisation by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond haemodynamic normalisation. EuroIntervention. (2018) 13:2060-2068.

Wardhana DA, Ikeda K, Barinda AJ, Nugroho DB, Qurania KR, Yagi K, Miyata K, Oike Y, Hirata KI, Emoto N. Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis. Proc Natl Acad Sci USA. (2018) 115:1529-1534.

2017年

Tamada N, Nakayama K, Shinkura Y, Yanaka K, Katayama N, Okada T, Yamaguchi M, Matsumoto K, Tanaka H, Shinke T, Emoto N, Hirata KI. Successful Pulmonary Artery Embolization for the Management of Hemoptysis in a Patient with Eisenmenger Syndrome Caused by Patent Ductus Arteriosus. Intern Med. (2017) 56:3299-3304.

Takeuchi K, Nakayama K, Okano M, Tamada N, Suehiro H, Shinkura Y, Yanaka K, Onishi H, Tanaka H, Shinke T, Emoto N, Hirata KI. Upfront triple combination therapy-induced pulmonary edema in a case of pulmonary arterial hypertension associated with Sjogren's syndrome. Respir Med Case Rep. (2017) 7;23:55-59.

Barinda AJ, Ikeda K, Hirata KI, Emoto N. Macrophages Highly Express Carbonic Anhydrase 2 and Play a Significant Role in Demineralization of the Ectopic Calcification. Kobe J Med Sci. (2017) 63: E45-E50.

Ogawa A, Satoh T, Fukuda T, Sugimura K, Fukumoto Y, Emoto N, Yamada N, Yao A, Ando M, Ogino H, Tanabe N, Tsujino I, Hanaoka M, Minatoya K, Ito H, Matsubara H. Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Results of a Multicenter Registry. Circ Cardiovasc Qual Outcomes. (2017) 10:e004029

Tsuboi Y, Tanaka H, Nishio R, Sawa T, Terashita D, Nakayama K, Satomi-Kobayashi S, Sakai Y, Emoto N, Hirata KI. Associations of Exercise Tolerance With Hemodynamic Parameters for Pulmonary Arterial Hypertension and for Chronic Thromboembolic Pulmonary Hypertension. J Cardiopulm Rehabil Prev. (2017) 37: 341-346.

Hayashi D, Yagi K, Song C, Ueda S, Yamanoue M, Topham M, Suzaki T, Saito N, Emoto N, Shirai Y. Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice. Sci Rep. (2017) 7: 2597.

Sano H, Tanaka H, Motoji Y, Fukuda Y, Mochizuki Y, Hatani Y, Matsuzoe H, Hatazawa K, Shimoura H, Ooka J, Ryo-Koriyama K, Nakayama K, Matsumoto K, Emoto N, Hirata KI. Right ventricular relative wall thickness as a predictor of outcomes and of right ventricular reverse remodeling for patients with pulmonary hypertension. Int J Cardiovasc Imaging. (2017) 33:313-321.

2016年

Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A. Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res Ther. (2016) 18: 113

Fukuda Y, Tanaka H, Ryo-Koriyama K, Motoji Y, Sano H, Shimoura H, Ooka J, Toki H, Sawa T, Mochizuki Y, Matsumoto K, Emoto N, Hirata KI. Comprehensive Functional Assessment of Right-Sided Heart Using Speckle Tracking Strain for Patients with Pulmonary Hypertension. Echocardiography. (2016)33: 1001-1008

Motoji Y, Tanaka H, Fukuda Y, Sano H, Ryo K, Sawa T, Miyoshi T, Imanishi J, Mochizuki Y, Tatsumi K, Matsumoto K, Emoto N, Hirata KI. Association of Apical Longitudinal Rotation with Right Ventricular Performance in Patients with Pulmonary Hypertension: Insights into Overestimation of Tricuspid Annular Plane Systolic Excursion. Echocardiography.(2016) 33: 207-215

2015年

Kinutani H, Shinke T, Nakayama K, Taniguchi Y, Otake H, Takaya T, Osue T, Konishi A, Emoto N, Hirata KI. High perfusion pressure as a predictor of reperfusion pulmonary injury after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. IJC Heart & Vasc. (2015)11:1-6.

Muliawan HS, Nakayama K, Yagi K, Ikeda K, Yagita K, Hirata K, Emoto N. Stable Somatic Gene Expression in Mouse Lungs Following Electroporation-mediated Tol2 Transposon Delivery. (2015) Kobe J Med Sci. 61(2):E47-53.

Satwiko MG, Ikeda K, Nakayama K, Yagi K, Hocher B, Hirata K, Emoto N. Targeted activation of endothelin-1 exacerbates hypoxia-induced pulmonary hypertension. (2015) Biochem Biophys Res Commun. 465(3):356-62.

Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Takamura K, Hanaoka M, Nishimura M, Tatsumi K; JRS Lung Disease PH Study Group. Multi-institutional retrospective cohort study of patients with severe pulmonary hypertension associated with respiratory diseases. (2015) Respirology. 20(5):805-12.

Sano H, Tanaka H, Motoji Y, Fukuda Y, Sawa T, Mochizuki Y, Ryo K, Matsumoto K, Emoto N, Hirata K. Right ventricular function and right-heart echocardiographic response to therapy predict long-term outcome in patients with pulmonary hypertension. (2015) Can J Cardiol. 31(4):529-36.

Motoji Y, Tanaka H, Fukuda Y, Sano H, Ryo K, Imanishi J, Miyoshi T, Sawa T, Mochizuki Y, Matsumoto K, Emoto N, Hirata K. Interdependence of right ventricular systolic function and left ventricular filling and its association with outcome for patients with pulmonary hypertension. (2015) Int J Cardiovasc Imaging. 331(4):691-8.

Matsuo K, Akakabe Y, Kitamura Y, Shimoda Y, Ono K, Ueyama T, Matoba S, Yamada H, Hatakeyama K, Asada Y, Emoto N, Ikeda K. Loss of apoptosis regulator through modulating IAP expression (ARIA) protects blood vessels from atherosclerosis. (2015) J Biol Chem. 290(6):3784-92.

Nakamoto H, Nakayama K, Emoto N, Kajiya F. The short-term effects of C-peptide on the early diabetes-related ultrastructural changes to the podocyte slit diaphragm of glomeruli in rats. (2015) Microcirculation. 22(2):122-32.

Teguh Ryanto GR, Nakayama K, Takaya T, Fujimoto D, Kinutani H, Shinkura Y, Mori S, Okada T, Nishii T, Kono A, Shinke T, Emoto N, Hirata K. Use of Coils and a Pulmonary Vasodilator to Reduce Pulmonary Hypertension in a Patient with Interstitial Pneumonia and Scleroderma. (2015) Intern Med. 54(21):2721-6.

Shimoda Y, Matsuo K, Kitamura Y, Ono K, Ueyama T, Matoba S, Yamada H, Wu T, Chen J, Emoto N, Ikeda K. Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle. (2015) PLoS One. 10(9):e0138624.

2014年

Emoto N, Yanagisawa M. The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. (2014) Life Sci. 118(2):70-6.

Emoto N, Masaki T, Goto K, Vanhoutte PM, Yanagisawa M. Endothelin XIII. (2014) Life Sci. 118(2):47-50.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. (2014) Life Sci. 118(2):77-86.

Emoto N, Kasuya Y, Yanagisawa M. The Second Tomoh Masaki Award 2013. (2014) Life Sci. 118(2):87-90.

Van Hung T, Emoto N, Vignon-Zellweger N, Nakayama K, Yagi K, Suzuki Y, Hirata KI. Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: Potential roles of interleukin-6 and endothelin. (2014) Life Sci. 24;118(2):313-328.

Fukuda Y, Tanaka H, Motoji Y, Ryo K, Sawa T, Imanishi J, Miyoshi T, Mochizuki Y, Tatsumi K, Matsumoto K, Shinke T, Emoto N, Hirata KI. Utility of combining assessment of right ventricular function and right atrial remodeling as a prognostic factor for patients with pulmonary hypertension. (2014) Int J Cardiovasc Imaging. 30(7):1269-1277.

Miyagawa K, Emoto N. Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension. (2014) Ther Adv Cardiovasc Dis. 8(5):202-216.

Taniguchi Y, Miyagawa K, Nakayama K, Kinutani H, Shinke T, Okada K, Okita Y, Hirata KI, Emoto N. Balloon pulmonary angioplasty: an additional treatment option to improve the prognosis of patients with chronic thromboembolic pulmonary hypertension. (2014) EuroIntervention. 10(4):518-25.

Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Miyaji K, Takamura K, Hayashi S, Hanaoka M, Tatsumi K; Japanese Respiratory Society Lung Disease Pulmonary Hypertension Study Group. Current trends in the management of pulmonary hypertension associated with respiratory disease in institutions approved by the Japanese Respiratory Society. (2014) Respir Investig. 52(3):167-172.

Taniguchi Y, Emoto N, Miyagawa K, Nakayama K, Kinutani H, Tanaka H, Shinke T, Okada K, Okita Y, Hirata KI. Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports: strategy for ASD with severe PAH. (2014) Heart Vessels. 29(2):282-285.

Nugrahaningsih DA, Emoto N, Vignon-Zellweger N, Purnomo E, Yagi K, Nakayama K, Doi M, Okamura H, Hirata K. Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice. (2014) Hypertens Res. 37(3):202-209.

Miyagawa K, Iwasa N, Nakayama K, Hirata K, Emoto N. Pregnancy and delivery in women with renovascular hypertension due to multiple intrarenal microaneurysms: a report of two cases. (2014) Intern Med. 53(20):2325-8.

Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H. Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing. (2014) PLoS One. 22;9(5):e97972.

Heiden S, Vignon-Zellweger N, Masuda S, Yagi K, Nakayama K, Yanagisawa M, Emoto N. Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice. (2014) PLoS One. 11;9(2):e88730.